Bliznakov E G, Watanabe T, Saji S, Folkers K
J Med. 1978;9(4):337-46.
The specific activities of the succinate dehydrogenase-coenzyme Q reductase were determined in mitochondria from the thymus and the spleen of aged mice (20, 22 and 24 months) as compared with young mice (10 weeks). Significant steep escalation of the deficiency of coenzyme Q-enzyme activity was observed in the thymus of all three groups of aged mice. No significant deficiency was found in the mitochondria of the spleen. The ratios between the liver weight:body weight and the spleen weight:body weight in young and aged mice are practically unchanged, but the thymus weight:body weight ratio decreases significantly in all three groups of aged mice. The described age-dependent anatomical and functional alterations in the thymus most likely form the base for the development of the T cell determined suppression of the immunological responsiveness, present in aged mice.
测定了老年小鼠（20、22和24月龄）胸腺和脾脏线粒体中琥珀酸脱氢酶 - 辅酶Q还原酶的比活性，并与年轻小鼠（10周龄）进行比较。在所有三组老年小鼠的胸腺中均观察到辅酶Q - 酶活性显著急剧下降。脾脏线粒体中未发现明显的活性下降。年轻和老年小鼠的肝脏重量与体重之比以及脾脏重量与体重之比实际未发生变化，但所有三组老年小鼠的胸腺重量与体重之比均显著降低。胸腺中所描述的与年龄相关的解剖学和功能改变很可能是老年小鼠中存在的由T细胞决定的免疫反应性抑制发展的基础。
