Dialysis Clinic, Inc., Albuquerque, New Mexico, USA.
University of New Mexico, Albuquerque, New Mexico, USA.
Kidney Int. 2017 May;91(5):1005-1007. doi: 10.1016/j.kint.2016.12.035.
Previous studies have demonstrated an association of serum uric acid with kidney disease. However, it is unknown whether this relationship is causal. Mendelian randomization takes advantage of allele randomization at birth to assess causation. Using this technique Ahola et al. found strong evidence against causation in Finnish Caucasians with type 1 diabetes mellitus. However, replication in other populations is needed to further assess a potential causal role for hyperuricemia in kidney disease.
先前的研究已经证明了血清尿酸与肾脏疾病之间的关联。然而，目前尚不清楚这种关系是否具有因果关系。孟德尔随机化利用出生时等位基因的随机分配来评估因果关系。使用这种技术，Ahola 等人在芬兰白种人 1 型糖尿病患者中发现了强有力的证据，表明尿酸升高与肾脏疾病之间没有因果关系。然而，需要在其他人群中进行复制，以进一步评估高尿酸血症在肾脏疾病中的潜在因果作用。
