Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, No 9 Jinsui Road, Tianhe District, Guangzhou, Guangdong Province, 510623, People's Republic of China.
Virol J. 2024 Mar 25;21(1):73. doi: 10.1186/s12985-024-02348-4.
Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes.
A two-sample Mendelian randomization (MR) analysis in this study was used to evaluate the casual relationships between COVID-19 infection and obstetric-related diseases based on genome-wide association studies (GWAS) dataset. Inverse-variance weighted (IVW), MR-Egger and MR-PRESSO were used to infer the connection and estimate the pleiotropy respectively.
The significant connection was observed between COVID-19 and placental disorders with beta of 1.57 and odds ratio (OR) of 4.81 (95% confidence interval [CI]: 1.05-22.05, p = 0.04). However, there were no associations between COVID-19 infection and gestational diabetes mellitus (GDM) (OR = 1.12; 95% CI: 0.85-1.45, p = 0.41), other disorders of amniotic fluid and membranes (OR = 0.90; 95% CI: 0.61-1.32, p = 0.59), Intrahepatic Cholestasis of Pregnancy (ICP) (OR = 1.42; 95% CI: 0.85-2.36, p = 0.18), birth weight (OR = 1.02; 95% CI: 0.99-1.05, p = 0.19), gestational hypertension (OR = 1.00; 95% CI: 1.00-1.00, p = 0.85), spontaneous miscarriages (OR = 1.00; 95% CI: 0.96-1.04, p = 0.90) and stillbirth (OR = 1.00; 95% CI: 0.98-1.01, p = 0.62).
There was no direct causal relationship between COVID-19 infection and maternal and neonatal poor outcomes. Our study could alleviate the anxiety of pregnant women under the COVID-19 pandemic conditions partly.
几项观察性研究表明，COVID-19 孕妇发生子痫前期和早产的风险更高。我们旨在确定 COVID-19 诊断的女性是否有不良妊娠结局。
本研究采用两样本 Mendelian 随机化 (MR) 分析，基于全基因组关联研究 (GWAS) 数据集评估 COVID-19 感染与产科相关疾病之间的因果关系。逆方差加权 (IVW)、MR-Egger 和 MR-PRESSO 分别用于推断关联和估计偏倚。
COVID-19 与胎盘疾病之间存在显著关联，beta 值为 1.57，比值比 (OR) 为 4.81 (95%置信区间 [CI]：1.05-22.05，p=0.04)。然而，COVID-19 感染与妊娠期糖尿病 (GDM) (OR=1.12；95% CI：0.85-1.45，p=0.41)、羊水和胎膜其他疾病 (OR=0.90；95% CI：0.61-1.32，p=0.59)、妊娠肝内胆汁淤积症 (ICP) (OR=1.42；95% CI：0.85-2.36，p=0.18)、出生体重 (OR=1.02；95% CI：0.99-1.05，p=0.19)、妊娠期高血压 (OR=1.00；95% CI：1.00-1.00，p=0.85)、自然流产 (OR=1.00；95% CI：0.96-1.04，p=0.90) 和死产 (OR=1.00；95% CI：0.98-1.01，p=0.62) 之间没有直接的因果关系。
COVID-19 感染与母婴不良结局之间没有直接的因果关系。我们的研究在一定程度上可以缓解 COVID-19 大流行期间孕妇的焦虑。
