Ohashi Y, Motojima S, Yamanouchi K, Makino S
Department of Medicine and Clinical Immunology, Dokkyo University School of Medicine, Tochigi, Japan.
Ann Allergy. 1988 Aug;61(2):109-15.
Enhanced bronchial reactivity to inhaled histamine was observed in guinea pigs infected with Sendai virus with concomitant decrease of beta-adrenergic receptor density in the pulmonary parenchyma 2 to 3 weeks after the inoculation. Histologic examination of the bronchi showed shedding of epithelial cells with a marked infiltration of mononuclear cells. These observations suggest that damage of the bronchial epithelium and decreased density of beta-adrenergic receptor may be the causes of observed bronchial reactivity.
