Chandra M
Nephrology Division, School of Medicine, University of Virginia, Charlottesville 22908.
Am J Vet Res. 1988 Jun;49(6):831-4.
A study was conducted to compare the responses of bursectomized (Bx) and nonbursectomized (non-Bx) specific-pathogen-free male chickens to Australian T strain of infectious bronchitis virus. Four chickens from each group were killed at 3, 5, 7, 14, 21, and 28 days after conjunctival inoculation of the virus. Clinical signs and gross and microscopic lesions were more severe in Bx than in non-Bx chickens. The non-Bx chickens had linear IgG deposits along the renal tubules. Virus-neutralizing titers were log10 2.74 to 4.33 for non-Bx chickens and less than log10 1.25 for the inoculated Bx and for broth-inoculated Bx and non-Bx chickens (controls). Early in the disease, renal lesions were of the same type in all infected chickens, but were more severe in Bx chickens. Later, nephritis was chronic and active in Bx chickens and was chronic in non-Bx chickens.
进行了一项研究，以比较去法氏囊（Bx）和未去法氏囊（非Bx）的无特定病原体雄性鸡对澳大利亚T株传染性支气管炎病毒的反应。在结膜接种病毒后的第3、5、7、14、21和28天，每组处死4只鸡。Bx鸡的临床症状、大体和显微镜下病变比非Bx鸡更严重。非Bx鸡的肾小管沿有线性IgG沉积。非Bx鸡的病毒中和滴度为log10 2.74至4.33，接种的Bx鸡以及肉汤接种的Bx鸡和非Bx鸡（对照）的病毒中和滴度低于log10 1.25。在疾病早期，所有感染鸡的肾脏病变类型相同，但Bx鸡的病变更严重。后来，Bx鸡的肾炎为慢性且活跃，而非Bx鸡的肾炎为慢性。
