Butcher G D, Winterfield R W, Shapiro D P
Department of Large Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville 32610.
Avian Dis. 1990 Oct-Dec;34(4):916-21.
A nephropathogenic Massachusetts strain of infectious bronchitis virus (IBV) designated H13-IBV was isolated from the kidneys of commercial broilers. H13-IBV caused respiratory distress, depression, and diarrhea in specific-pathogen-free chickens. Gross renal lesions included pale coloration, swelling, and urate deposition. Histologic renal changes were interstitial mononuclear cell infiltration and degeneration and necrosis of tubular epithelial cells. Lesions in respiratory tissues included thickening and edema of the air sacs, congestion of the tracheal mucosa, and frothy serous exudate. Histologic tracheal lesions were deciliation, mucous gland distortion, inflammatory cell infiltration, and squamous metaplasia. Clinically, H13-IBV was highly pathogenic in birds infected at 1 day of age and mildly pathogenic in birds infected at 4 weeks of age. Kidney lesions were of marked severity only in birds infected at 1 day of age. Tracheal lesions were similar in severity in both age groups.
一种肾致病性马萨诸塞州传染性支气管炎病毒（IBV）毒株，命名为H13-IBV，是从商品肉鸡的肾脏中分离出来的。H13-IBV在无特定病原体的鸡中引起呼吸窘迫、抑郁和腹泻。肾脏肉眼病变包括颜色变淡、肿胀和尿酸盐沉积。肾脏组织学变化为间质单核细胞浸润以及肾小管上皮细胞变性和坏死。呼吸组织的病变包括气囊增厚和水肿、气管黏膜充血以及泡沫状浆液性渗出物。气管组织学病变为纤毛脱落、黏液腺变形、炎性细胞浸润和鳞状化生。临床上，H13-IBV对1日龄感染的禽类具有高致病性，对4周龄感染的禽类具有低致病性。仅1日龄感染的禽类肾脏病变严重。两个年龄组的气管病变严重程度相似。
