Fast Laura A, Lieber Diana, Lang Thorsten, Florin Luise
Department of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Institute of Virology, Ulm University Medical Center, Ulm, Germany.
Biochem Soc Trans. 2017 Apr 15;45(2):489-497. doi: 10.1042/BST20160295.
Members of the tetraspanin family have been identified as essential cellular membrane proteins in infectious diseases by nearly all types of pathogens. The present review highlights recently published data on the role of tetraspanin CD151, CD81, and CD63 and their interaction partners in host cell entry by human cytomegalo- and human papillomaviruses. Moreover, we discuss a model for tetraspanin assembly into trafficking platforms at the plasma membrane. These platforms might persist during intracellular viral trafficking.
四跨膜蛋白家族的成员已被几乎所有类型的病原体鉴定为传染病中必不可少的细胞膜蛋白。本综述重点介绍了最近发表的关于四跨膜蛋白CD151、CD81和CD63及其相互作用伙伴在人巨细胞病毒和人乳头瘤病毒进入宿主细胞中的作用的数据。此外，我们讨论了四跨膜蛋白组装成质膜上运输平台的模型。这些平台可能在细胞内病毒运输过程中持续存在。
