一种用于腺病毒疫苗接种的新仓鼠模型。
A new hamster model for adenoviral vaccination.
作者信息
Hjorth R N, Bonde G M, Pierzchala W A, Vernon S K, Wiener F P, Levner M H, Lubeck M D, Hung P P
机构信息
Wyeth Labs, Inc., Microbiology Division, Philadelphia, Pennsylvania.
出版信息
Arch Virol. 1988;100(3-4):279-83. doi: 10.1007/BF01487691.
Both adult and baby hamsters infected intranasally with human adenovirus type 5 exhibited virologic, serologic, and histologic evidence of infection. When 8-day old hamsters were infected with 4 x 10(6) pfu, concentrations of virus up to 2 x 10(6) pfu/animal were detected in the lung, peaking on day 2. The minimum infectious dose was 1 x 10(3) pfu/animal. This model may be useful in studies of conventional and recombinant adenoviral vaccines for humans.
经鼻内接种人5型腺病毒的成年和幼年仓鼠均表现出感染的病毒学、血清学和组织学证据。当8日龄仓鼠接种4×10⁶空斑形成单位（pfu）时，在肺中检测到高达2×10⁶ pfu/只动物的病毒浓度，在第2天达到峰值。最小感染剂量为1×10³ pfu/只动物。该模型可能有助于人类传统和重组腺病毒疫苗的研究。
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