Jeong Jiwoon, Park Changhoon, Kang Ikjae, Park Su-Jin, Chae Chanhee
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
Can J Vet Res. 2017 Apr;81(2):108-117.
The objective of the present study was to determine the effect of concurrent vaccination of boars with type 1 and type 2 porcine reproductive and respiratory syndrome virus (PRRSV) on seminal shedding of both genotypes. The boars tolerated well concurrent administration of 2 commercial PRRSV vaccines, and no adverse reactions were observed. No interference in the humoral immune response (measured as the level of anti-PRRSV antibodies) or the cell-mediated immune response (measured as the level of PRRSV-specific interferon-γ-secreting cells) was observed after concurrent administration compared with single administration of the same vaccines. Concurrent vaccination significantly reduced the load of type 1 and type 2 PRRSV in blood and semen after singular (type 1 or type 2) and dual (type 1 and type 2) PRRSV challenge, and it did not significantly affect the efficacy of each vaccine. The results demonstrate that concurrent vaccination of boars with type 1 and type 2 PRRSV reduces shedding of both genotypes in semen.
本研究的目的是确定用1型和2型猪繁殖与呼吸综合征病毒（PRRSV）同时对公猪进行疫苗接种，对两种基因型病毒精液排毒的影响。公猪对同时接种2种市售PRRSV疫苗耐受性良好，未观察到不良反应。与单独接种相同疫苗相比，同时接种后未观察到对体液免疫反应（以抗PRRSV抗体水平衡量）或细胞介导免疫反应（以PRRSV特异性分泌干扰素-γ的细胞水平衡量）的干扰。在单次（1型或2型）和双重（1型和2型）PRRSV攻毒后，同时接种显著降低了血液和精液中1型和2型PRRSV的载量，且未显著影响每种疫苗的效力。结果表明，用1型和2型PRRSV同时对公猪进行疫苗接种可减少精液中两种基因型病毒的排毒。
