Foley Jennifer A, Foltynie Tom, Zrinzo Ludvic, Hyam Jonathan A, Limousin Patricia, Cipolotti Lisa
National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
UCL Institute of Neurology, Queen Square, London, UK.
Behav Neurol. 2017;2017:7348101. doi: 10.1155/2017/7348101. Epub 2017 Mar 20.
. Reduced verbal fluency is a strikingly uniform finding following deep brain stimulation (DBS) for Parkinson's disease (PD). The precise cognitive mechanism underlying this reduction remains unclear, but theories have suggested reduced motivation, linguistic skill, and/or executive function. It is of note, however, that previous reports have failed to consider the potential role of any changes in speed of processing. Thus, the aim of this study was to examine verbal fluency changes with a particular focus on the role of cognitive speed. . In this study, 28 patients with PD completed measures of verbal fluency, motivation, language, executive functioning, and speed of processing, before and after DBS. . As expected, there was a marked decline in verbal fluency but also in a timed test of executive functions and two measures of speed of processing. Verbal fluency decline was associated with markers of linguistic and executive functioning, but not after speed of processing was statistically controlled for. In contrast, greater decline in verbal fluency was associated with higher levels of apathy at baseline, which was not associated with changes in cognitive speed. . Reduced generativity and processing speed may account for the marked reduction in verbal fluency commonly observed following DBS.
对于帕金森病（PD）患者，在进行脑深部电刺激（DBS）后，言语流畅性降低是一个极为一致的发现。这种降低背后的确切认知机制尚不清楚，但有理论认为可能是动机、语言技能和/或执行功能降低所致。然而，值得注意的是，先前的报告未能考虑加工速度变化的潜在作用。因此，本研究的目的是检查言语流畅性的变化，特别关注认知速度的作用。
在本研究中，28名帕金森病患者在接受DBS前后完成了言语流畅性、动机、语言、执行功能和加工速度的测量。
正如预期的那样，言语流畅性显著下降，执行功能的定时测试以及两项加工速度测量指标也出现下降。言语流畅性下降与语言和执行功能指标相关，但在对加工速度进行统计学控制后则不然。相比之下，言语流畅性下降幅度更大与基线时更高水平的冷漠相关，而冷漠与认知速度变化无关。
生成能力和加工速度降低可能是DBS后常见的言语流畅性显著降低的原因。
