Real-world diagnosis in patients referred for esophagoduodenoscopy: The gap between guidelines and clinical practice.

BACKGROUND AND AIMS

Histopathology is the most accurate test to detect when performed correctly with unknown validity in daily practice clinic settings. We aimed to determine the rate of potentially false-negative results that might be due to continued use of proton pump inhibitors (PPIs) in routine endoscopy practice. We also aimed to establish whether gastroenterologists recommend routine cessation of PPIs before esophagogastroduodenoscopy (EGD) and whether they regularly document that biopsies for testing have been taken while the patients are on PPI treatment.

METHODS

Detailed information about three known factors (PPIs, antibiotics and prior eradication treatment), which may cause histology or rapid urease test (RUT) to be unreliable, had been prospectively collected through interviews using a questionnaire before each test. Gastric biopsies were stained with H&E for histological analysis.

RESULTS

A total of 409 individuals at three academic gastroenterology institutions were tested 200 times with histology. Fifty-six per cent (68 of 122) of all negative tests fell in the category of continuing PPI use, which had the potential to make the histology and RUT results unreliable.

CONCLUSIONS

These data demonstrate a clear and important gap between current guidelines and real-world practice with regards to the diagnosis of during EGD. A negative histology or RUT should be considered false negative until potential protocol violations are excluded. Documentation of PPI use during the EGD should be an integral part of the EGD report. The current practice of taking biopsies for testing in patients under PPIs should be reevaluated.