Tanuskova Dominika, Horakova Julia, Svec Peter, Bodova Ivana, Lengerova Martina, Bezdicek Matej, Poczova Miroslava, Koppl Jozef, Kolenova Alexandra
Department of Paediatric Haematology and Oncology, Comenius University Children's Hospital, Bratislava, Slovakia.
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czechia.
Med Mycol Case Rep. 2017 Mar 31;16:12-15. doi: 10.1016/j.mmcr.2017.03.004. eCollection 2017 Jun.
(previously known as or or ) is a rare cause of fungal infection in immunocompromised patients. Most of these cases (87%) have been reported from the Mediterranean region, as it is extremely rare to recognize it in other regions. Here we report a first case of disseminated infection in Slovakia. The patient - 19 year old woman with myelodysplastic syndrome was diagnosed with fungemia after allogeneic stem cell transplantation. The infection occurred despite antifungal prophylaxis with micafungin, which was sensitive to the yeast. The treatment according to minimal inhibitory concentrations (micafungin, voriconazol) and granulocyte transfusions were administered. was cleared out from the bloodstream. However, patient died of multiple organ failure. Autopsy showed multiple lesions in organs, but did not prove presence of yeast by histopathology. was confirmed by polymerase chain reaction from all tested organs: heart, brain, lungs, spleen, liver and kidneys. We present the post mortem pictures showing the yeast lesions in affected organs. 2012 Elsevier Ltd. All rights reserved.
（以前称为 或 或 ）是免疫功能低下患者真菌感染的罕见原因。这些病例大多数（87%）报告来自地中海地区，因为在其他地区极难识别。在此我们报告斯洛伐克首例播散性 感染病例。该患者——一名患有骨髓增生异常综合征的19岁女性，在异基因干细胞移植后被诊断为 真菌血症。尽管使用对该酵母菌敏感的米卡芬净进行了抗真菌预防，但仍发生了感染。根据最低抑菌浓度进行治疗（米卡芬净、伏立康唑）并输注粒细胞。 从血液中清除。然而，患者死于多器官功能衰竭。尸检显示器官有多处病变，但组织病理学未证实有酵母菌存在。通过聚合酶链反应在所有检测器官（心脏、大脑、肺、脾脏、肝脏和肾脏）中均确认了 。我们展示了受影响器官中酵母菌病变的尸检图片。2012爱思唯尔有限公司。保留所有权利。
