Curtin William M, Millington Karmaine A, Ibekwe Tochi O, Ural Serdar H
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology & Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Department of Pathology & Laboratory Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Biomed Res Int. 2017;2017:3723879. doi: 10.1155/2017/3723879. Epub 2017 Mar 20.
Our objective was determining if abnormal Doppler evaluation had a higher prevalence of placental pathology compared to normal Doppler in suspected fetal growth restriction (FGR) of cases delivered at 37 weeks. This retrospective cohort study of suspected FGR singletons with antenatal Doppler evaluation delivered at 37 weeks had a primary outcome of the prevalence of placental pathology related to FGR. Significance was defined as ≤ 0.05. Of 100 pregnancies 46 and 54 were in the abnormal and normal Doppler cohorts, respectively. Placental pathology was more prevalent with any abnormal Doppler, 84.8% versus 55.6%, odds ratio (OR) 4.46, 95% confidence interval (CI): 1.55, 13.22, and = 0.002. Abnormal middle cerebral artery (MCA) Doppler had a higher prevalence: 96.2% versus 54.8%, OR 20.7, 95% CI: 2.54, 447.1, and < 0.001. Abnormal Doppler was associated with more placental pathology in comparison to normal Doppler in fetuses with suspected FGR. Abnormal MCA Doppler had the strongest association.
我们的目的是确定在37周分娩的疑似胎儿生长受限（FGR）病例中，与正常多普勒检查相比，异常多普勒评估的胎盘病理发生率是否更高。这项对37周分娩的疑似FGR单胎妊娠进行产前多普勒评估的回顾性队列研究的主要结果是与FGR相关的胎盘病理发生率。显著性定义为≤0.05。在100例妊娠中，异常多普勒队列和正常多普勒队列分别有46例和54例。任何异常多普勒检查时胎盘病理更为普遍，分别为84.8%和55.6%，优势比（OR）为4.46，95%置信区间（CI）：1.55，13.22，P = 0.002。异常大脑中动脉（MCA）多普勒检查时发生率更高：分别为96.2%和54.8%，OR为20.7，95%CI：2.54，447.1，P < 0.001。在疑似FGR的胎儿中，与正常多普勒检查相比，异常多普勒与更多的胎盘病理相关。异常MCA多普勒检查的相关性最强。
