野生动物（野生鸟类）在全球传播抗微生物药物耐药性基因中的作用。
The role of wildlife (wild birds) in the global transmission of antimicrobial resistance genes.
机构信息
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
出版信息
Zool Res. 2017 Mar 18;38(2):55-80. doi: 10.24272/j.issn.2095-8137.2017.003.
Abstract
Antimicrobial resistance is an urgent global health challenge in human and veterinary medicine. Wild animals are not directly exposed to clinically relevant antibiotics; however, antibacterial resistance in wild animals has been increasingly reported worldwide in parallel to the situation in human and veterinary medicine. This underlies the complexity of bacterial resistance in wild animals and the possible interspecies transmission between humans, domestic animals, the environment, and wildlife. This review summarizes the current data on expanded-spectrum β-lactamase (ESBL), AmpC β-lactamase, carbapenemase, and colistin resistance genes in isolates of wildlife origin. The aim of this review is to better understand the important role of wild animals as reservoirs and vectors in the global dissemination of crucial clinical antibacterial resistance. In this regard, continued surveillance is urgently needed worldwide.
摘要
抗微生物药物耐药性是人类和兽医医学领域的一项紧迫的全球卫生挑战。野生动物不会直接接触到具有临床相关性的抗生素；然而，与人类和兽医医学的情况类似，世界各地野生动物中的抗菌药物耐药性的报道也越来越多。这突显了野生动物中细菌耐药性的复杂性以及人类、家畜、环境和野生动物之间可能发生的种间传播。本综述总结了野生动物来源分离株中扩展谱β-内酰胺酶（ESBL）、AmpCβ-内酰胺酶、碳青霉烯酶和黏菌素耐药基因的现有数据。本综述的目的是更好地理解野生动物作为关键临床抗菌药物耐药性在全球传播的储主和载体的重要作用。在这方面，全世界都迫切需要进行持续监测。
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