Freire Sandryelle Merces, Kyllar Annelise, Côrtes Marina, Chagas Thiago P G, Pinheiro Felipe, Pereira Renata F A, Aguiar-Alves Fabio, Penna Bruno
Laboratório de Cocos Gram Positivos do Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil.
Instituto de Medicina Tropical da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Sci Rep. 2025 Jul 1;15(1):20814. doi: 10.1038/s41598-025-97816-4.
The growing prevalence of antimicrobial resistance poses a global threat to human and animal health. In this study, we investigated the occurrence and genetic basis of antimicrobial resistance in a Magellanic Penguin (Spheniscus magellanicus) rescued off the coast of Rio de Janeiro, Brazil. The penguin presented a bacterial infection, identified as Klebsiella pneumoniae. Molecular analysis revealed the presence of several resistance genes, including those that confer resistance to carbapenems, beta-lactams, quinolones, and other classes of antibiotics. The bacterial strain belonged to Sequence Type 70 (ST70), a clone previously associated with human nosocomial infections. This study highlights the potential of migratory penguins as vectors of antimicrobial-resistant microorganisms, emphasizing the need for a One Health approach to address the complex interaction between environmental factors, animal health, and human well-being. The findings underscore the urgency of implementing strategies to mitigate the spread of multidrug-resistant bacteria in natural and urban environments.
抗菌药物耐药性的日益普遍对人类和动物健康构成了全球威胁。在本研究中，我们调查了在巴西里约热内卢海岸获救的麦哲伦企鹅（Spheniscus magellanicus）中抗菌药物耐药性的发生情况及其遗传基础。这只企鹅出现了细菌感染，经鉴定为肺炎克雷伯菌。分子分析显示存在多个耐药基因，包括那些赋予对碳青霉烯类、β-内酰胺类、喹诺酮类和其他类抗生素耐药性的基因。该细菌菌株属于序列型70（ST70），这是一个先前与人类医院感染相关的克隆。本研究强调了迁徙企鹅作为抗菌药物耐药微生物载体的可能性，强调需要采取“同一健康”方法来应对环境因素、动物健康和人类福祉之间的复杂相互作用。这些发现强调了实施战略以减轻多重耐药细菌在自然和城市环境中传播的紧迫性。
