Cohen Robert, Cohen Jérémie François, Chalumeau Martin, Levy Corinne
a Université Paris Est , IMRB-GRC GEMINI, Créteil , France.
b ACTIV, Association Clinique et Thérapeutique Infantile du Val de Marne , Saint-Maur des Fossés , France.
Expert Rev Vaccines. 2017 Jun;16(6):625-640. doi: 10.1080/14760584.2017.1320221. Epub 2017 Apr 28.
The high level of effectiveness of pneumococcal conjugate vaccines (PCVs) was demonstrated initially in high-income countries (HICs). However, because the burden of pneumococcal diseases (PDs) is greater in non-high-income countries (NHICs) than HICs, the assessment of these vaccines in this latter setting is crucial. Areas covered: PubMed was used to search for literature related to the effectiveness of PCVs. Several studies described the effectiveness of PCVs in NHICs, and we compare the impact of PCVs on the incidence of invasive pneumococcal disease (IPD) and pneumonia in HICs and NHICs. Expert commentary: Implementation of PCVs has been effective in both HICs and NHICs. The decline in overall incidence of PD is due to the disappearance of most vaccine serotypes, which is straightforward and comparable across the different settings. As expected, the decrease in overall incidence of PD was eroded in part by the increasing incidence of IPD due to non-vaccine serotypes. We need to continue a multi-faceted surveillance of IPD and carriage.
肺炎球菌结合疫苗（PCV）的高效性最初在高收入国家得到证实。然而，由于非高收入国家（NHIC）的肺炎球菌疾病（PD）负担比高收入国家（HIC）更重，因此在后者环境中评估这些疫苗至关重要。涵盖领域：使用PubMed搜索与PCV有效性相关的文献。多项研究描述了PCV在NHIC中的有效性，我们比较了PCV对HIC和NHIC中侵袭性肺炎球菌疾病（IPD）和肺炎发病率的影响。专家评论：PCV的实施在HIC和NHIC中均有效。PD总体发病率的下降是由于大多数疫苗血清型消失，这在不同环境中是直接且可比的。正如预期的那样，PD总体发病率的下降部分被非疫苗血清型导致的IPD发病率上升所抵消。我们需要继续对IPD和携带情况进行多方面监测。
