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1
Distinct Serum Sphingolipid Profiles among School-aged Children with Exercise-induced Wheeze and Asthma Persistence.运动诱发性喘息和哮喘持续存在的学龄儿童中不同的血清鞘脂谱。
Am J Respir Crit Care Med. 2017 Apr 15;195(8):1068-1070. doi: 10.1164/rccm.201609-1884LE.
2
Case 3: presentation. Dyspnoea without wheeze unlikely to be caused by asthma.病例3：临床表现。无哮鸣音的呼吸困难不太可能由哮喘引起。
Paediatr Respir Rev. 2001 Jun;2(2):196, 198.
3
Exercise-induced wheeze, urgent medical visits, and neighborhood asthma prevalence.运动诱发的喘息、紧急医疗就诊和邻里哮喘患病率。
Pediatrics. 2013 Jan;131(1):e127-35. doi: 10.1542/peds.2012-1072. Epub 2012 Dec 17.
4
[Exercise-induced inspiratory stridor. An important differential diagnosis of exercise-induced asthma].[运动诱发的吸气性喘鸣。运动诱发哮喘的重要鉴别诊断]
Ugeskr Laeger. 2007 Nov 19;169(47):4047-50.
5
Exercise-induced wheezing among Japanese pre-school children and pupils.日本学龄前儿童和小学生运动诱发的喘息
Allergol Int. 2014 Jun;63(2):251-9. doi: 10.2332/allergolint.13-OA-0644. Epub 2014 Apr 25.
6
A simple asthma prediction tool for preschool children with wheeze or cough.一种用于有喘息或咳嗽的学龄前儿童的简单哮喘预测工具。
J Allergy Clin Immunol. 2014 Jan;133(1):111-8.e1-13. doi: 10.1016/j.jaci.2013.06.002. Epub 2013 Jul 24.
7
[Exercise-induced asthma could be laryngeal obstruction. Not uncommon among young sportsmen--avoiding the wrong treatment is important].运动诱发性哮喘可能是喉部阻塞。在年轻运动员中并不罕见——避免错误治疗很重要。
Lakartidningen. 2009;106(38):2351-3.
8
Exertional dyspnea and inspiratory stridor of 2 years' duration: a tale of 2 wheezes.持续2年的劳力性呼吸困难和吸气性喘鸣：两种哮鸣音的故事
J Allergy Clin Immunol. 2011 Nov;128(5):1135-6.e1-10. doi: 10.1016/j.jaci.2011.09.021.
9
A 9-year-old girl who was wheezing for 3 months.一名喘息3个月的9岁女孩。
Pediatr Ann. 2010 Jan;39(1):7-8, 10-11. doi: 10.3928/00904481-20091210-01.
10
I'm OK: therapy by advertised inaccurate assertion.我没事：通过宣传不准确断言进行治疗。
JAMA. 1986 Sep 5;256(9):1139-40.

引用本文的文献

1
Independent association of a 17q21 variant with exacerbations in type 2-low adult asthma.17q21变异与2型低龄成人哮喘病情加重的独立关联。
J Allergy Clin Immunol Glob. 2025 Jun 10;4(3):100511. doi: 10.1016/j.jacig.2025.100511. eCollection 2025 Aug.
2
Specific microRNA Profile Associated with Inflammation and Lipid Metabolism for Stratifying Allergic Asthma Severity.与炎症和脂代谢相关的特定 microRNA 谱用于分层变应性哮喘严重程度。
Int J Mol Sci. 2024 Aug 30;25(17):9425. doi: 10.3390/ijms25179425.
3
Metabolic Contributions to Pathobiology of Asthma.代谢对哮喘病理生物学的影响。
Metabolites. 2023 Jan 31;13(2):212. doi: 10.3390/metabo13020212.
4
Sphingolipids and Asthma.鞘脂类和哮喘。
Adv Exp Med Biol. 2022;1372:145-155. doi: 10.1007/978-981-19-0394-6_10.
5
Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma.慢性肺病的围产期起源：机制 - 预防 - 治疗 - 鞘脂代谢与儿童哮喘的遗传及围产期起源
Mol Cell Pediatr. 2021 Dec 20;8(1):22. doi: 10.1186/s40348-021-00130-y.
6
The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review.儿童过敏性疾病的代谢组学：全面的特定途径综述
Metabolites. 2020 Dec 16;10(12):511. doi: 10.3390/metabo10120511.
7
Increased expression of serine palmitoyl transferase and ORMDL3 polymorphism are associated with eosinophilic inflammation and airflow limitation in aspirin-exacerbated respiratory disease.丝氨酸棕榈酰转移酶表达增加和 ORMDL3 多态性与阿司匹林加重的呼吸道疾病中的嗜酸性粒细胞炎症和气流受限有关。
PLoS One. 2020 Oct 8;15(10):e0240334. doi: 10.1371/journal.pone.0240334. eCollection 2020.
8
Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity.增加神经鞘脂合成可减轻气道高反应性。
Am J Respir Cell Mol Biol. 2020 Nov;63(5):690-698. doi: 10.1165/rcmb.2020-0194OC.
9
At last - linking ORMDL3 polymorphisms, decreased sphingolipid synthesis, and asthma susceptibility.终于 - 连接 ORMDL3 多态性、鞘脂合成减少和哮喘易感性。
J Clin Invest. 2020 Feb 3;130(2):604-607. doi: 10.1172/JCI134333.
10
Decreased sphingolipid synthesis in children with 17q21 asthma-risk genotypes.17q21哮喘风险基因型儿童中鞘脂合成减少。
J Clin Invest. 2020 Feb 3;130(2):921-926. doi: 10.1172/JCI130860.

本文引用的文献

1
Ceramide Signaling and Metabolism in Pathophysiological States of the Lung.肺病理生理状态下的神经酰胺信号传导与代谢
Annu Rev Physiol. 2016;78:463-80. doi: 10.1146/annurev-physiol-021115-105221. Epub 2015 Nov 30.
2
Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.异常的ORM（酵母）样蛋白异构体3（ORMDL3）表达会破坏细胞内的神经酰胺稳态，而神经酰胺会加剧小鼠的过敏性哮喘。
J Allergy Clin Immunol. 2015 Oct;136(4):1035-46.e6. doi: 10.1016/j.jaci.2015.02.031. Epub 2015 Apr 2.
3
Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.呼吸道中鞘脂合成受损可导致气道高反应性。
Sci Transl Med. 2013 May 22;5(186):186ra67. doi: 10.1126/scitranslmed.3005765.
4
Exercise-induced wheeze, urgent medical visits, and neighborhood asthma prevalence.运动诱发的喘息、紧急医疗就诊和邻里哮喘患病率。
Pediatrics. 2013 Jan;131(1):e127-35. doi: 10.1542/peds.2012-1072. Epub 2012 Dec 17.
5
Analysis of sphingolipids in extracted human plasma using liquid chromatography electrospray ionization tandem mass spectrometry.采用液相色谱-电喷雾串联质谱法分析提取人血浆中的神经酰胺。
Anal Biochem. 2012 Apr 15;423(2):187-94. doi: 10.1016/j.ab.2012.01.027. Epub 2012 Jan 31.
6
A large-scale, consortium-based genomewide association study of asthma.一项基于大型联盟的哮喘全基因组关联研究。
N Engl J Med. 2010 Sep 23;363(13):1211-1221. doi: 10.1056/NEJMoa0906312.
7
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.调控ORMDL3表达的基因变异会增加儿童患哮喘的风险。
Nature. 2007 Jul 26;448(7152):470-3. doi: 10.1038/nature06014. Epub 2007 Jul 4.

Distinct Serum Sphingolipid Profiles among School-aged Children with Exercise-induced Wheeze and Asthma Persistence.

作者信息

Perzanowski Matthew S, Ono Jennie G, Acosta Luis M, Kim Benjamin I, Divjan Adnan, Miller Rachel, Rundle Andrew, Worgall Stefan, Worgall Tilla S

机构信息

1 Columbia University New York, New York.

2 Weill Cornell Medical College New York, New York and.

出版信息

Am J Respir Crit Care Med. 2017 Apr 15;195(8):1068-1070. doi: 10.1164/rccm.201609-1884LE.

DOI:10.1164/rccm.201609-1884LE
PMID:28409682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5422650/
Abstract
摘要