Franco F, Snart R S
Department of Zoology, The University, Sheffield, U.K.
Biochim Biophys Acta. 1988 Jul 29;970(3):287-91. doi: 10.1016/0167-4889(88)90128-0.
We have investigated the effect of mineralocorticoids on intestinal fluid and electrogenic glucose-linked Na+ transport across isolated sections of the rat small intestine. A rapid in vitro response is observed that contrast with the delay normally associated with steroid hormone responses. Cyclic AMP is known to affect intestinal glucose, water and Na+ transport and the effects of the steroids may be understood in terms of an inhibitory effect on intestinal cyclic AMP production. An inhibitory effect of the steroids on membrane-bound adenylate cyclase has been demonstrated and dose-response effects suggest the presence of specific membrane-bound glucocorticoid receptors.
我们研究了盐皮质激素对大鼠小肠离体节段肠液及与葡萄糖相关的电中性钠转运的影响。观察到一种快速的体外反应，这与通常与类固醇激素反应相关的延迟形成对比。已知环磷酸腺苷（cAMP）会影响肠道葡萄糖、水和钠的转运，而类固醇的作用可从其对肠道cAMP生成的抑制作用来理解。已证实类固醇对膜结合型腺苷酸环化酶有抑制作用，剂量反应效应表明存在特异性的膜结合型糖皮质激素受体。
