Ryu Dong-Woo, Lee Si-Hoon, Oh Yoon-Sang, An Jae-Young, Park Jeong-Wook, Song In-Uk, Lee Kwang-Soo, Kim Joong-Seok
J Parkinsons Dis. 2017;7(2):369-376. doi: 10.3233/JPD-160992.
Recent genetic and epidemiological studies have shown that there is a link between essential tremor and Parkinson's disease (PD). However, there is a lack of data about the clinical features of PD developed from essential tremor.
To explore and describe the clinical characteristics of Parkinson's disease developed from essential tremor (ET-PD).
Twenty-five ET-PD patients and 124 IPD controls were enrolled according to each criterion. Motor and non-motor features and dopamine transporter uptake were compared between the two groups.
Rest and action tremors were more severe in ET-PD patients than in IPD patients. In addition, tremor disorder of first-degree relatives occurred more frequently in the ET-PD group than in the IPD group. A comparison between cases with ET-PD and IPD was not significant for striatal dopamine transporter uptake. Among the non-motor features, sleep disorder frequency, especially rapid-eye-movement sleep behavioral disorder, were lower in patients with ET-PD than in those with IPD, and smell identification test scores were higher in patients with ET-PD than in those with IPD. The prevalence of other non-motor symptoms did not differ between the two groups.
This is the first comparison of motor and non-motor features between ET-PD and IPD. ET-PD and IPD have different characteristic motor and non-motor features from the nosologic perspective.
近期的遗传学和流行病学研究表明，特发性震颤与帕金森病（PD）之间存在联系。然而，关于由特发性震颤发展而来的帕金森病的临床特征的数据却很缺乏。
探讨并描述由特发性震颤发展而来的帕金森病（ET-PD）的临床特征。
根据各项标准纳入25例ET-PD患者和124例IPD对照。比较两组的运动和非运动特征以及多巴胺转运体摄取情况。
ET-PD患者的静止性和动作性震颤比IPD患者更严重。此外，ET-PD组一级亲属的震颤障碍发生率高于IPD组。ET-PD病例与IPD病例在纹状体多巴胺转运体摄取方面的比较无显著差异。在非运动特征方面，ET-PD患者的睡眠障碍频率，尤其是快速眼动睡眠行为障碍，低于IPD患者，而ET-PD患者的嗅觉识别测试得分高于IPD患者。两组间其他非运动症状的患病率无差异。
这是首次对ET-PD和IPD的运动和非运动特征进行比较。从疾病分类学角度来看，ET-PD和IPD具有不同的特征性运动和非运动特征。
