Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA,
Front Biosci (Landmark Ed). 2017 Jun 1;22(11):1845-1866. doi: 10.2741/4575.
Viruses are important human and animal pathogens causing disease that affect global health and the economy. One outcome of many virus infections is the regulation of cellular trafficking machinery. Viral proteins recruit and interact with cellular trafficking proteins to divert the normal trafficking of key proteins or to induce the formation of novel membrane structures in the host cell. These alterations often increase replication efficiency by mislocalizing immune regulators or restriction factors ot by creating platforms for replication and assembly of new virus particles. Our knowledge of how viruses interact with the cellular trafficking machinery is still limited and furthering this understanding will be important for the future development of prophylactic and therapeutic treatments. This review provides a glimpse of the types of interplay between viral and cellular factors that result in a disruption of cellular trafficking or modifications to cellular membranes.
病毒是重要的人类和动物病原体，可导致疾病，影响全球健康和经济。许多病毒感染的结果之一是调节细胞运输机制。病毒蛋白招募和相互作用与细胞运输蛋白，以改变关键蛋白的正常运输，或诱导在宿主细胞中形成新的膜结构。这些改变通常通过使免疫调节剂或限制因子错位，或通过为新病毒颗粒的复制和组装创建平台来提高复制效率。我们对病毒与细胞运输机制相互作用的了解仍然有限，进一步了解这一点对于未来预防性和治疗性治疗的发展将是重要的。本综述提供了病毒和细胞因子之间相互作用的类型的一个 glimpse，这些相互作用导致细胞运输的破坏或细胞膜的修饰。
