Gene expression of the central and peripheral nervous system myelin membrane 2', 3'-cyclic nucleotide 3'-phosphodiesterase in development.

Determination of gene expression for the 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP) during development shows that the amount of translatable RNA encoding this enzyme increases in parallel with myelination in the mouse brain. The two isoforms of this enzyme are developmentally regulated in parallel, in contrast to several other myelin proteins. By comparison, the amount of translatable RNA encoding CNP in the peripheral nervous system (rat sciatic nerve) remains constant during development. The two isoforms that are expressed are identical in apparent molecular weight to rat brain CNP. Moreover, no apparent differences were detected by proteolytic digestion (Cleveland mapping) of CNP 1 from the central or peripheral nervous systems.