2016 年塞内加尔肠道病毒 D68 亚分支 B3 的传播情况：从流感样疾病和急性弛缓性麻痹监测中检测到。
Enterovirus D68 Subclade B3 Circulation in Senegal, 2016: Detection from Influenza-like Illness and Acute Flaccid Paralysis Surveillance.
机构信息
Institut Pasteur de Dakar, Département de Virologie, Dakar, Senegal.
Institut Pasteur de Dakar, Unité d'Epidémiologie des maladies infectieuses, Dakar, Senegal.
出版信息
Sci Rep. 2019 Sep 25;9(1):13881. doi: 10.1038/s41598-019-50470-z.
Following the 2014 outbreak, active surveillance of the EV-D68 has been implemented in many countries worldwide. Despite subsequent EV-D68 outbreaks (2014 and 2016) reported in many areas, EV-D68 circulation remains largely unexplored in Africa except in Senegal, where low levels of EV-D68 circulation were first noted during the 2014 outbreak. Here we investigate subsequent epidemiology of EV-D68 in Senegal from June to September 2016 by screening respiratory specimens from ILI and stool from AFP surveillance. EV-D68 was detected in 7.4% (44/596) of patients; 40 with ILI and 4 with AFP. EV-D68 detection was significantly more common in children under 5 years (56.8%, p = 0.016). All EV-D68 strains detected belonged to the newly defined subclade B3. This study provides the first evidence of EV-D68 B3 subclade circulation in Africa from patients with ILI and AFP during a 2016 outbreak in Senegal. Enhanced surveillance of EV-D68 is needed to better understand the epidemiology of EV-D68 in Africa.
自 2014 年疫情爆发以来，全球许多国家都在对 EV-D68 进行积极监测。尽管在许多地区随后报告了 EV-D68 的爆发（2014 年和 2016 年），但除了塞内加尔，EV-D68 的传播在非洲仍未得到广泛研究，在塞内加尔，EV-D68 的传播在 2014 年的疫情中首次被发现。在此，我们通过对 ILI 患者的呼吸道标本和 AFP 监测的粪便标本进行筛查，调查了 2016 年 6 月至 9 月塞内加尔的 EV-D68 后续流行病学情况。EV-D68 在 7.4%（44/596）的患者中被检测到；40 例为 ILI，4 例为 AFP。在 5 岁以下儿童中，EV-D68 的检出率明显更高（56.8%，p=0.016）。所有检测到的 EV-D68 株均属于新定义的亚谱系 B3。本研究首次在塞内加尔 2016 年的疫情中，从 ILI 和 AFP 患者中发现了非洲 EV-D68 B3 亚谱系的传播。需要加强对 EV-D68 的监测，以更好地了解非洲 EV-D68 的流行病学情况。
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