Institut Pasteur de Dakar, Département de Virologie, Dakar, Senegal.
Institut Pasteur de Dakar, Unité d'Epidémiologie des maladies infectieuses, Dakar, Senegal.
Sci Rep. 2019 Sep 25;9(1):13881. doi: 10.1038/s41598-019-50470-z.
Following the 2014 outbreak, active surveillance of the EV-D68 has been implemented in many countries worldwide. Despite subsequent EV-D68 outbreaks (2014 and 2016) reported in many areas, EV-D68 circulation remains largely unexplored in Africa except in Senegal, where low levels of EV-D68 circulation were first noted during the 2014 outbreak. Here we investigate subsequent epidemiology of EV-D68 in Senegal from June to September 2016 by screening respiratory specimens from ILI and stool from AFP surveillance. EV-D68 was detected in 7.4% (44/596) of patients; 40 with ILI and 4 with AFP. EV-D68 detection was significantly more common in children under 5 years (56.8%, p = 0.016). All EV-D68 strains detected belonged to the newly defined subclade B3. This study provides the first evidence of EV-D68 B3 subclade circulation in Africa from patients with ILI and AFP during a 2016 outbreak in Senegal. Enhanced surveillance of EV-D68 is needed to better understand the epidemiology of EV-D68 in Africa.
自 2014 年疫情爆发以来，全球许多国家都在对 EV-D68 进行积极监测。尽管在许多地区随后报告了 EV-D68 的爆发（2014 年和 2016 年），但除了塞内加尔，EV-D68 的传播在非洲仍未得到广泛研究，在塞内加尔，EV-D68 的传播在 2014 年的疫情中首次被发现。在此，我们通过对 ILI 患者的呼吸道标本和 AFP 监测的粪便标本进行筛查，调查了 2016 年 6 月至 9 月塞内加尔的 EV-D68 后续流行病学情况。EV-D68 在 7.4%（44/596）的患者中被检测到；40 例为 ILI，4 例为 AFP。在 5 岁以下儿童中，EV-D68 的检出率明显更高（56.8%，p=0.016）。所有检测到的 EV-D68 株均属于新定义的亚谱系 B3。本研究首次在塞内加尔 2016 年的疫情中，从 ILI 和 AFP 患者中发现了非洲 EV-D68 B3 亚谱系的传播。需要加强对 EV-D68 的监测，以更好地了解非洲 EV-D68 的流行病学情况。
