Mai Hong-Cheng, Chen Dan-Xia, Lu Dan, Zhang Yu-Sheng
Department of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, P.R. China.
Mol Clin Oncol. 2017 Apr;6(4):543-546. doi: 10.3892/mco.2017.1190. Epub 2017 Mar 9.
Extranodal natural killer (NK)/T-cell lymphomas are rare, highly aggressive tumors of the central nervous system (CNS) that commonly affect the nasal cavity or paranasal sinuses. NK/T-cell lymphomas are associated with a poor prognosis, as they exhibit a wide range of unique clinical presentations and neuroimaging findings that are currently difficult to detect. Pathological examination is considered to be more reliable for defining the pathological entity of NK/T-cell lymphoma. Early testing for fluorodeoxyglucose (FDG)-positron emission tomography combined with computed tomography may improve the evaluation of lymphomas, which have been known to display avid FDG uptake. The authors herein report a case of NK/T-cell lymphoma presenting with cavernous sinus syndrome involving the CNS via direct extension from the nose. NK/T-cell lymphomas are very aggressive, with an unfavorable clinical outcome, and the optimal therapy has not yet been clearly defined.
结外自然杀伤（NK）/T细胞淋巴瘤是中枢神经系统（CNS）罕见的高侵袭性肿瘤，通常累及鼻腔或鼻窦。NK/T细胞淋巴瘤预后较差，因为它们表现出广泛的独特临床表现和神经影像学表现，目前难以检测。病理检查被认为对于定义NK/T细胞淋巴瘤的病理实体更为可靠。早期进行氟脱氧葡萄糖（FDG）-正电子发射断层扫描联合计算机断层扫描可能会改善对已知表现为FDG摄取增加的淋巴瘤的评估。本文作者报告1例NK/T细胞淋巴瘤，该病例通过从鼻部直接蔓延累及中枢神经系统，表现为海绵窦综合征。NK/T细胞淋巴瘤极具侵袭性，临床结局不佳，目前尚未明确最佳治疗方案。
