Brummitt C F, Cherrington J M, Katzenstein D A, Juni B A, Van Drunen N, Edelman C, Rhame F S, Jordan M C
Department of Medicine (Division of Infectious Diseases), University of Minnesota Medical School, Minneapolis.
J Infect Dis. 1988 Aug;158(2):423-32. doi: 10.1093/infdis/158.2.423.
An immunocompromised woman died of disseminated infection due to adenovirus type 3. During her hospitalization and after her death, 38 hospital personnel developed an acute respiratory illness. Adenovirus type 3 infection was documented by culture in 18 of the 38 individuals and by seroconversion in one additional employee. Four of 34 asymptomatic hospital personnel exposed to the index case also seroconverted. Thus, 23 personnel were considered to have confirmed infections, and 22 of these 23 reported direct contact with the index case. Acquisition of infection was associated with the number and type of contacts. Protection against infection was associated with detectable serum-neutralizing antibody in the early serological sample. Restriction enzyme analysis using six different endonucleases indicated that all isolates of virus were type 3a and had identical genetic composition. This study underscores the importance of adenovirus as a cause of nosocomial infection and indicates that genetic analysis of viral DNA is a powerful tool for studying common-source outbreaks.
一名免疫功能低下的女性死于3型腺病毒引起的播散性感染。在她住院期间及死后，38名医院工作人员患上了急性呼吸道疾病。38人中18人的感染通过培养确诊为3型腺病毒感染，另有一名工作人员通过血清学转换确诊。34名接触过首例病例的无症状医院工作人员中有4人也发生了血清学转换。因此，23名工作人员被认为确诊感染，这23人中的22人报告与首例病例有直接接触。感染的获得与接触的数量和类型有关。预防感染与早期血清学样本中可检测到的血清中和抗体有关。使用六种不同核酸内切酶的限制性酶切分析表明，所有病毒分离株均为3a型，且基因组成相同。本研究强调了腺病毒作为医院感染病因的重要性，并表明病毒DNA的基因分析是研究共同来源暴发的有力工具。
