Tsichlaki A, O'Brien K, Johal A, Fleming P S
Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
School of Dentistry, University of Manchester, Manchester, UK.
Orthod Craniofac Res. 2017 May;20(2):55-64. doi: 10.1111/ocr.12152.
The aim of this study was to identify and summarize the outcomes measured in orthodontic studies of children with cleft lip and/or palate. The objectives were to categorize the outcomes into pre-determined domains and to explore whether any domains were under-represented. Electronic databases and grey literature were searched until December 2016 to identify all studies of orthodontic treatment interventions in children and adolescents with cleft lip and palate. Abstracts and subsequently eligible full-text articles were screened independently and in duplicate by two reviewers. All reported outcome measures were identified and categorized into six predetermined outcome domains. The search identified 833 abstracts. The majority of studies did not assess orthodontic interventions and were therefore not eligible for inclusion. Consequently, following screening 71 eligible articles were retrieved in full, of which 40 met the inclusion criteria. Morphological features of malocclusion were measured in 27 studies (68%) and adverse effects of orthodontic treatment in 10 (25%). Functional status (n=4; 10%), physical consequences of malocclusion (n=3; 7.5%), quality of life (n=3; 7.5%) and health resource utilization (n=2; 5%) were rarely considered. Relatively few studies concerning patients with cleft lip and palate focused on orthodontic interventions. Most of the identified outcomes were concerned with measuring morphological treatment-related changes and do not reflect patient perspectives.
本研究的目的是识别和总结唇腭裂儿童正畸研究中所测量的结果。目标是将结果分类到预先确定的领域，并探讨是否有任何领域未得到充分体现。检索电子数据库和灰色文献直至2016年12月，以识别所有关于唇腭裂儿童和青少年正畸治疗干预的研究。摘要及随后符合条件的全文文章由两名评审员独立且重复筛选。识别所有报告的结果测量指标并将其分类到六个预先确定的结果领域。检索共识别出833篇摘要。大多数研究未评估正畸干预措施，因此不符合纳入标准。结果，经过筛选后，共检索到71篇符合条件的全文文章，其中40篇符合纳入标准。27项研究（68%）测量了错牙合畸形的形态特征，10项研究（25%）测量了正畸治疗的不良反应。功能状态（n = 4；10%）、错牙合畸形的身体后果（n = 3；7.5%）、生活质量（n = 3；7.5%）和卫生资源利用（n = 2；5%）很少被考虑。相对而言，关注唇腭裂患者的正畸干预研究较少。大多数已识别的结果关注于测量与治疗相关的形态学变化，并未反映患者的观点。
