Khashaba Pakinaz Y, Ali Hassan Refat H, El-Wekil Mohamed M
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Deraya University, El-Minya, Egypt.
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Egypt.
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:733-741. doi: 10.1016/j.msec.2017.02.092. Epub 2017 Feb 24.
Pencil graphite electrode was successfully modified with a thin film of poly (eriochrome black T) and applied for the sensitive and selective voltammetric simultaneous determination of pantoprazole sodium and domperidone in a binary mixture. The preparation and basic electrochemical behavior of poly (eriochrome black T) film on the Pencil graphite electrode were investigated. The modified electrode has exhibited very high electro-catalytic activity towards the cited mixture. The anodic peaks of the both species were well defined with enhanced oxidation peak currents. Under the optimum conditions, the linearity ranges were 0.4-55×10M and 0.1-34×10M for pantoprazole sodium and domperidone, respectively with detection limits of 0.12×10M and 0.04×10M for pantoprazole sodium and domperidone, respectively. The proposed sensor has been successfully applied in the analysis of pantoprazole sodium and domperidone in synthetic binary mixtures and human serum.
用聚（铬黑T）薄膜成功修饰铅笔石墨电极，并将其用于二元混合物中泮托拉唑钠和多潘立酮的灵敏且选择性伏安法同时测定。研究了聚（铬黑T）薄膜在铅笔石墨电极上的制备及其基本电化学行为。修饰电极对上述混合物表现出非常高的电催化活性。两种物质的阳极峰都清晰可辨，氧化峰电流增强。在最佳条件下，泮托拉唑钠和多潘立酮的线性范围分别为0.4 - 55×10⁻⁶M和0.1 - 34×10⁻⁶M，泮托拉唑钠和多潘立酮的检测限分别为0.12×10⁻⁶M和0.04×10⁻⁶M。所提出的传感器已成功应用于合成二元混合物和人血清中泮托拉唑钠和多潘立酮的分析。
