Stücker Isabelle, Martin Diane, Neri Monica, Laurent-Puig Pierre, Blons Hélène, Antoine Martine, Guiochon-Mantel Anne, Brailly-Tabard Sylvie, Canonico Marianne, Wislez Marie, Trédaniel Jean
Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, Inserm UMRS1018, 94807, Villejuif, France.
Université Paris Descartes, Inserm UMR 5775 EPIGENETEC, 75006, Paris, France.
BMC Public Health. 2017 Apr 17;17(1):324. doi: 10.1186/s12889-017-4191-1.
Lung cancer aetiology and clinical aspects have been mainly studied in men, although specific risk factors probably exist in women. Here we present the rationale, design and organization of the WELCA study (Women Epidemiology Lung CAncer) that has been launched to investigate lung cancer in women, focusing particularly on hormonal and occupational factors.
METHODS/DESIGN: WELCA is a population based case-control study and planned to recruit 1000 cases and 1000 controls in three years, based on study power calculation. Eligible cases are female patients newly diagnosed with lung cancer, living in Paris and the Ile de France area and aged up to 75 years. Almost all Parisian pneumology and oncology clinical departments are involved. The control group is a random sample of the population living in the same area, frequency-matched on age and additionally stratified on the distribution of socio-professional categories of women residing there. After acquisition of written consent, research nurses administer standardized computer assisted questionnaires to all the subjects in face-to-face interviews and acquire anthropometric measures. Besides usual socio-demographic characteristics, information is gathered about menstrual and reproductive factors, hormonal treatments, lifestyle and leisure characteristics, occupational history, personal and familial medical history. Biological samples are also collected, in order to establish a biobank for molecular epidemiology studies. Molecular characteristics of the tumours will be obtained and patients will be followed up for five years.
The WELCA study aims to answer key questions in lung cancer aetiology and clinical characteristics specifically in women. The role of hormonal impregnation is investigated, and the interactions with cigarette smoking or body mass index (BMI) will be analyzed in detail. The occupational history of the subjects is carefully reconstructed, focusing in particular on the service sector. The creation of a biobank for collection of serum, plasma, DNA and tumour tissue will allow the genetic and biochemical characterization of both the subjets and the tumours. The follow-up of the patients will help in disentangling the role of hormonal factors and tumour molecular characteristics in survival.
肺癌的病因学和临床方面主要是在男性中进行研究的，尽管女性可能存在特定的风险因素。在此，我们介绍了WELCA研究（女性肺癌流行病学研究）的基本原理、设计和组织情况，该研究已启动，旨在调查女性肺癌，特别关注激素和职业因素。
方法/设计：WELCA是一项基于人群的病例对照研究，根据研究效能计算，计划在三年内招募1000例病例和1000名对照。符合条件的病例是新诊断为肺癌的女性患者，居住在巴黎和法兰西岛地区，年龄在75岁及以下。几乎所有巴黎的肺病和肿瘤临床科室都参与其中。对照组是居住在同一地区人群的随机样本，按年龄进行频率匹配，并根据居住在该地区的女性社会职业类别分布进行额外分层。在获得书面同意后，研究护士通过面对面访谈向所有受试者发放标准化的计算机辅助问卷，并获取人体测量数据。除了通常的社会人口学特征外，还收集有关月经和生殖因素、激素治疗、生活方式和休闲特征、职业史、个人和家族病史的信息。还收集生物样本，以建立一个用于分子流行病学研究的生物库。将获取肿瘤的分子特征，并对患者进行五年随访。
WELCA研究旨在回答肺癌病因学和临床特征方面的关键问题，特别是针对女性患者。研究调查了激素影响的作用，并将详细分析其与吸烟或体重指数（BMI）的相互作用。仔细重建受试者的职业史，尤其关注服务业。创建一个用于收集血清、血浆、DNA和肿瘤组织的生物库，将有助于对受试者和肿瘤进行基因和生化特征分析。对患者的随访将有助于厘清激素因素和肿瘤分子特征在生存中的作用。
