Zhou Huaqiang, Zhang Yuanzhe, Song Yiyan, Tan Wulin, Qiu Zeting, Li Si, Chen Qinchang, Gao Shaowei
Department of Anesthesia, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan 2 Road, Guangzhou 510080, China; Sun Yat-sen University School of Medicine, Guangzhou, China.
Sun Yat-sen University School of Medicine, Guangzhou, China.
Clin Res Hepatol Gastroenterol. 2017 Sep;41(4):476-486. doi: 10.1016/j.clinre.2017.02.008. Epub 2017 Apr 14.
Marital status's prognostic impact on pancreatic neuroendocrine tumors (PNET) has not been rigorously studied. We aimed to explore the relationship between marital status and outcomes of PNET.
We retrospectively investigated 2060 PNET cases between 2004 and 2010 from Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Chi test, t-test as appropriate. Kaplan-Meier methods and COX proportional hazard models were used to ascertain independent prognostic factors.
Married patients had better 5-year overall survival (OS) (53.37% vs. 42.27%, P<0.001) and 5-year pancreatic neuroendocrine tumor specific survival (PNSS) (67.76% vs. 59.82%, P=0.001) comparing with unmarried patients. Multivariate analysis revealed marital status is an independent prognostic factor, with married patients showing better OS (HR=0.74; 95% CI: 0.65-0.84; P<0.001) and PNSS (HR=0.78; 95% CI: 0.66-0.92; P=0.004). Subgroup analysis suggested marital status plays a more important role in the PNET patients with distant stage rather than regional or localized disease.
Marital status is an independent prognostic factor for survival in PNET patients. Poor prognosis in unmarried patients may be associated with a delayed diagnosis with advanced tumor stage, psychosocial and socioeconomic factors. Further studies are needed.
婚姻状况对胰腺神经内分泌肿瘤（PNET）预后的影响尚未得到严格研究。我们旨在探讨婚姻状况与PNET预后之间的关系。
我们回顾性调查了2004年至2010年监测、流行病学和最终结果（SEER）数据库中的2060例PNET病例。变量通过卡方检验、适当的t检验进行比较。采用Kaplan-Meier方法和COX比例风险模型确定独立预后因素。
与未婚患者相比，已婚患者的5年总生存率（OS）更高（53.37%对42.27%，P<0.001），5年胰腺神经内分泌肿瘤特异性生存率（PNSS）更高（67.76%对59.82%，P=0.001）。多因素分析显示婚姻状况是一个独立的预后因素，已婚患者的OS更好（HR=0.74；95%CI：0.65-0.84；P<0.001），PNSS更好（HR=0.78；95%CI：0.66-0.92；P=0.004）。亚组分析表明，婚姻状况在远处转移期而非区域或局限性疾病的PNET患者中起更重要的作用。
婚姻状况是PNET患者生存的独立预后因素。未婚患者预后较差可能与肿瘤晚期诊断延迟、心理社会和社会经济因素有关。需要进一步研究。
