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细菌因子VopL/F介导的肌动蛋白丝组装：哪一端朝上？

Actin filament assembly by bacterial factors VopL/F: Which end is up?

作者信息

Vizcarra Christina L, Quinlan Margot E

机构信息

Department of Chemistry, Barnard College, New York, NY 10027.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095

出版信息

J Cell Biol. 2017 May 1;216(5):1211-1213. doi: 10.1083/jcb.201702165. Epub 2017 Apr 17.

DOI:10.1083/jcb.201702165
PMID:28416477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5412575/
Abstract

Competing models have been proposed for actin filament nucleation by the bacterial proteins VopL/F. In this issue, Burke et al. (2017. https://doi.org/10.1083/jcb.201608104) use direct observation to demonstrate that VopL/F bind the barbed and pointed ends of actin filaments but only nucleate new filaments from the pointed end.

摘要

关于细菌蛋白VopL/F介导肌动蛋白丝成核作用，已经提出了多种相互竞争的模型。在本期杂志中，伯克等人（2017年。https://doi.org/10.1083/jcb.201608104）通过直接观察证明，VopL/F可结合肌动蛋白丝的尖端和尾端，但仅从尾端形成新的肌动蛋白丝。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9b3/5412575/c0a99392a5e7/JCB_201702165_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9b3/5412575/c0a99392a5e7/JCB_201702165_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9b3/5412575/c0a99392a5e7/JCB_201702165_Fig1.jpg

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本文引用的文献

1
The bacterial virulence factors VopL and VopF nucleate actin from the pointed end.细菌毒力因子VopL和VopF从肌动蛋白的尖端起始使肌动蛋白成核。
J Cell Biol. 2017 May 1;216(5):1267-1276. doi: 10.1083/jcb.201608104. Epub 2017 Mar 31.
2
The WH2 Domain and Actin Nucleation: Necessary but Insufficient.WH2结构域与肌动蛋白成核：必要但不充分。
Trends Biochem Sci. 2016 Jun;41(6):478-490. doi: 10.1016/j.tibs.2016.03.004. Epub 2016 Apr 5.
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The bacterial effector VopL organizes actin into filament-like structures.细菌效应蛋白 VopL 将肌动蛋白组装成类似纤维的结构。
Cell. 2013 Oct 10;155(2):423-34. doi: 10.1016/j.cell.2013.09.019.
4
Dimeric WH2 domains in Vibrio VopF promote actin filament barbed-end uncapping and assisted elongation.Vibrio VopF 的二聚 WH2 结构域促进肌动蛋白丝的帽状末端解聚和辅助延伸。
Nat Struct Mol Biol. 2013 Sep;20(9):1069-76. doi: 10.1038/nsmb.2639. Epub 2013 Aug 4.
5
Multiple forms of Spire-actin complexes and their functional consequences.Spire-actin 复合物的多种形式及其功能后果。
J Biol Chem. 2012 Mar 23;287(13):10684-10692. doi: 10.1074/jbc.M111.317792. Epub 2012 Feb 8.
6
Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation.细菌 VopL 通过肌动蛋白丝成核的机制及其对串联 W 结构域成核的影响。
Nat Struct Mol Biol. 2011 Aug 28;18(9):1060-7. doi: 10.1038/nsmb.2109.
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Mechanism of actin filament nucleation by the bacterial effector VopL.细菌效应蛋白 VopL 引发肌动蛋白丝成核的机制。
Nat Struct Mol Biol. 2011 Aug 28;18(9):1068-74. doi: 10.1038/nsmb.2110.
8
Analysis of the function of Spire in actin assembly and its synergy with formin and profilin.Spire在肌动蛋白组装中的功能及其与formin和profilin协同作用的分析。
Mol Cell. 2007 Nov 30;28(4):555-68. doi: 10.1016/j.molcel.2007.09.018.
9
A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization.霍乱弧菌中的III型分泌系统转运一种formin/spire杂合样肌动蛋白成核因子以促进肠道定殖。
Cell Host Microbe. 2007 Apr 19;1(2):95-107. doi: 10.1016/j.chom.2007.03.005.
10
Drosophila Spire is an actin nucleation factor.果蝇Spire是一种肌动蛋白成核因子。
Nature. 2005 Jan 27;433(7024):382-8. doi: 10.1038/nature03241.