Naylor Mark F, Zhou Feifan, Geister Brian V, Nordquist Robert E, Li Xiaosong, Chen Wei R
Baylor Scott & White Healthcare, Waco, Texas, 76712, USA.
Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, Oklahoma, 73034, USA.
J Biophotonics. 2017 May;10(5):618-622. doi: 10.1002/jbio.201600271. Epub 2017 Apr 18.
Immunotherapy has become a promising modality for melanoma, especially using checkpoint inhibitors, which revive suppressed T cells against the cancer. Such inhibitors should work better when combined with other treatments which could increase the number and quality of anti-tumor T cells. We treated one patient with advanced (stage IV) melanoma, using the combination of laser immunotherapy (LIT), a novel immunological approach for metastatic cancers that has been shown to stimulate adaptive immunity, and ipilimumab. The patient was treated with LIT, followed with one course of ipilimumab 3 months after the beginning of LIT. After LIT treatment, all treated cutaneous melanoma in head and neck cleared completely. After the application of ipilimumab, all the tumor nodules in the lungs decreased. The patient had remained tumor free for one year. While anecdotal, the responses seen in this patient support the hypothesis that laser immunotherapy increases the number and quality of anti-tumor T cells so that ipilimumab and other checkpoint inhibitors are more effective in enhancing the therapeutic effects. Picture: Schematic of treatment using laser immunotherapy and ipilimumab on a stage IV melanoma patient.
免疫疗法已成为黑色素瘤一种很有前景的治疗方式，尤其是使用检查点抑制剂，这类抑制剂可使被抑制的抗癌T细胞恢复活性。当与其他能够增加抗肿瘤T细胞数量和质量的治疗方法联合使用时，此类抑制剂的效果应该会更好。我们对一名晚期（IV期）黑色素瘤患者进行了治疗，采用了激光免疫疗法（LIT）和伊匹单抗联合治疗，激光免疫疗法是一种针对转移性癌症的新型免疫疗法，已被证明可刺激适应性免疫。该患者接受了激光免疫疗法治疗，并在激光免疫疗法开始3个月后接受了一个疗程的伊匹单抗治疗。激光免疫疗法治疗后，头颈部所有接受治疗的皮肤黑色素瘤完全清除。应用伊匹单抗后，肺部所有肿瘤结节均缩小。该患者已无瘤生存一年。尽管这只是个例，但该患者的反应支持了这样一种假说，即激光免疫疗法可增加抗肿瘤T细胞的数量和质量，从而使伊匹单抗和其他检查点抑制剂在增强治疗效果方面更有效。图：IV期黑色素瘤患者使用激光免疫疗法和伊匹单抗治疗的示意图。
