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Cancer Therapy: Shooting for the Moon.

作者信息

Lee Jsh, Blumenthal G M, Hohl R J, Huang S-M

机构信息

Office of the Director, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Office of Hematology & Oncology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

出版信息

Clin Pharmacol Ther. 2017 May;101(5):552-558. doi: 10.1002/cpt.655.

DOI:10.1002/cpt.655
PMID:28418166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5525193/
Abstract
摘要

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Cancer Therapy: Shooting for the Moon.癌症治疗：向月球进发。
Clin Pharmacol Ther. 2017 May;101(5):552-558. doi: 10.1002/cpt.655.
2
Cancer research in the United States: A critical review of current status and proposal for alternative models.美国的癌症研究：对当前状况的批判性审视及替代模式建议
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Repurposing Drugs in Oncology: Next Steps.肿瘤学中药物的重新利用：下一步举措。
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Losing sight of our primary target: curing cancer.忽视了我们的首要目标：治愈癌症。
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New drugs meeting in Washington: too demanding for clinicians?新药研讨会在华盛顿召开：对临床医生要求过高？
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The special treatment.特殊治疗。
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Evolution of Next Generation Therapeutics: Past, Present, and Future of Precision Medicines.下一代治疗方法的演变：精准医学的过去、现在与未来
Clin Transl Sci. 2019 Nov;12(6):560-563. doi: 10.1111/cts.12675. Epub 2019 Aug 23.
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Health Care Evolves From Reactive to Proactive.医疗保健从被动反应式向主动前瞻性转变。
Clin Pharmacol Ther. 2019 Jan;105(1):10-13. doi: 10.1002/cpt.1295.
3
Process Improvement for Maximized Therapeutic Innovation Outcome.通过流程改进实现治疗创新成果最大化。
Clin Pharmacol Ther. 2018 Jan;103(1):8-12. doi: 10.1002/cpt.929.

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Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.合作以竞争：癌症血液图谱联盟（BloodPAC）
Clin Pharmacol Ther. 2017 May;101(5):589-592. doi: 10.1002/cpt.666. Epub 2017 Apr 12.
2
Collaboration to Accelerate Proteogenomics Cancer Care: The Department of Veterans Affairs, Department of Defense, and the National Cancer Institute's Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Network.加速蛋白质基因组学癌症护理的合作：美国退伍军人事务部、国防部以及美国国立癌症研究所的应用蛋白质基因组学组织学习与成果（APOLLO）网络。
Clin Pharmacol Ther. 2017 May;101(5):619-621. doi: 10.1002/cpt.658.
3
Optimizing treatment for patients with anaplastic lymphoma kinase-positive lung cancer.优化间变性淋巴瘤激酶阳性肺癌患者的治疗
Clin Pharmacol Ther. 2017 May;101(5):625-633. doi: 10.1002/cpt.653. Epub 2017 Mar 17.
4
Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.为何基于模型的精准给药尚未成为普遍的临床现实？从过去吸取的经验教训以及未来的路线图。
Clin Pharmacol Ther. 2017 May;101(5):646-656. doi: 10.1002/cpt.659. Epub 2017 Apr 4.
5
Artificial intelligence (AI) systems for interpreting complex medical datasets.用于解释复杂医学数据集的人工智能（AI）系统。
Clin Pharmacol Ther. 2017 May;101(5):585-586. doi: 10.1002/cpt.650. Epub 2017 Mar 17.
6
Translation and Clinical Development of Bispecific T-cell Engaging Antibodies for Cancer Treatment.用于癌症治疗的双特异性T细胞衔接抗体的翻译与临床开发
Clin Pharmacol Ther. 2017 May;101(5):634-645. doi: 10.1002/cpt.651.
7
Centers for Medicare & Medicaid Services' Oncology Care Model: Delivering Higher Value Cancer Care.医疗保险和医疗补助服务中心的肿瘤护理模式：提供更高价值的癌症护理。
Clin Pharmacol Ther. 2017 May;101(5):569-571. doi: 10.1002/cpt.638.
8
Cancer Moonshot Data and Technology Team: Enabling a National Learning Healthcare System for Cancer to Unleash the Power of Data.癌症“登月计划”数据与技术团队：助力构建国家癌症学习型医疗体系以释放数据力量。
Clin Pharmacol Ther. 2017 May;101(5):613-615. doi: 10.1002/cpt.636.
9
Clinical Considerations for Oncolytic Viral Therapies: A Regulatory Perspective.溶瘤病毒疗法的临床考量：监管视角
Clin Pharmacol Ther. 2017 May;101(5):580-582. doi: 10.1002/cpt.640. Epub 2017 Apr 12.
10
Toward greater insights on pharmacokinetics and exposure-response relationships for therapeutic biologics in oncology drug development.在肿瘤药物研发中，深入了解治疗性生物制品的药代动力学和暴露-反应关系。
Clin Pharmacol Ther. 2017 May;101(5):582-584. doi: 10.1002/cpt.628. Epub 2017 Mar 15.