Allina D O, Andreeva Yu Yu, Zavalishina L E, Moskvina L V, Frank G A
Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow, Russia.
Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow, Russia; Clinical Hospital One, Presidential Administration of the Russian Federation, Moscow, Russia.
Arkh Patol. 2017;79(2):10-14. doi: 10.17116/patol201779210-14.
The differential diagnosis of benign and malignant changes in the prostate presents still definite difficulties; the antibody panel existing for these purposes is imperfect. Fatty acid synthase (FASN) is an androgen-regulated enzyme required for de novo lipogenesis. A number of studies have noted increased expression of the gene encoding this protein in tumors and precancerous lesions of different locations.
Тo estimate the diagnostic value of analyzing the expression of FASN in prostate neoplasias.
Surgical specimens were selected for study from 71 patients with prostate cancer during radical prostatectomy. An immunohistochemical method was used to analyze FASN expression.
The expression of FASN was observed to be moderate or intensive in adenocarcinoma and high-grade prostatic intraepithelial neoplasia (hPIN) in all the study samples while 2 cases showed none and weak expression of AMACR. In benign lesions, the expression of this protein was identified only in 3 cases and it was characterized by a low-intensity staining.
The study has shown that the high frequency of FASN expression in hPIN and cancer and no expression in most structures of benign hyperplasia make it possible to use this protein as an additional marker in the differential diagnosis of prostatic neoplasms.
前列腺良性和恶性病变的鉴别诊断仍然存在一定困难；为此目的现有的抗体组合并不完善。脂肪酸合酶（FASN）是一种从头合成脂肪所需的雄激素调节酶。多项研究指出，编码该蛋白的基因在不同部位的肿瘤和癌前病变中表达增加。
评估分析FASN在前列腺肿瘤中的表达的诊断价值。
从71例前列腺癌患者根治性前列腺切除术中选取手术标本进行研究。采用免疫组织化学方法分析FASN的表达。
在所有研究样本中，腺癌和高级别前列腺上皮内瘤变（hPIN）中FASN表达为中度或强阳性，而2例AMACR无表达或弱阳性。在良性病变中，该蛋白仅在3例中表达，且表现为低强度染色。
研究表明，hPIN和癌症中FASN表达频率高，而良性增生的大多数结构中无表达，这使得该蛋白有可能作为前列腺肿瘤鉴别诊断的一种辅助标志物。
