Datta Palika, Rewers-Felkins Kathleen, Kallem Raja Reddy, Baker Teresa, Hale Thomas W
1 Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
2 School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
J Hum Lact. 2017 May;33(2):296-299. doi: 10.1177/0890334417695207. Epub 2017 Mar 20.
Aspirin has antipyretic and anti-inflammatory properties and is frequently used by pregnant and lactating women. However, its transfer in human milk when administered at low dose has not been reported. Research aim: This study aimed to evaluate the transfer of acetylsalicylic acid and its metabolite, salicylic acid, into human milk following the use of low dose aspirin.
In this study, milk samples were collected at 0, 1, 2, 4, 8, 12, and 24 hours from seven breastfeeding women after a steady-state daily dose of 81 mg of aspirin. Milk levels of acetylsalicylic acid and salicylic acid were determined by liquid chromatography-tandem mass spectrometry.
Acetylsalicylic acid levels were below the limit of quantification (0.61 ng/ml) in all the milk samples, whereas salicylic acid was detected at very low concentrations. The average concentration of salicylic acid observed was 24 ng/ml and the estimated relative infant dose was 0.4%.
Acetylsalicylic acid transfer into milk is so low that it is undetectable even by highly sophisticated methodology. Salicylic acid does appear in the human milk in comparatively low amounts, which are probably subclinical in infants. Thus, the daily use of an 81-mg dose of aspirin should be considered safe during lactation.
阿司匹林具有解热和抗炎特性，经常被孕妇和哺乳期妇女使用。然而，低剂量服用时其在母乳中的转移情况尚未见报道。研究目的：本研究旨在评估低剂量阿司匹林使用后乙酰水杨酸及其代谢产物水杨酸在母乳中的转移情况。
在本研究中，7名哺乳期妇女在每日稳定服用81毫克阿司匹林后，于0、1、2、4、8、12和24小时采集母乳样本。采用液相色谱-串联质谱法测定母乳中乙酰水杨酸和水杨酸的含量。
所有母乳样本中乙酰水杨酸含量均低于定量限（0.61纳克/毫升），而水杨酸的检测浓度非常低。观察到的水杨酸平均浓度为24纳克/毫升，估计相对婴儿剂量为0.4%。
乙酰水杨酸向母乳中的转移量极低，即使采用高度精密的方法也无法检测到。水杨酸确实会以相对较低的量出现在母乳中，这对婴儿可能无临床意义。因此，哺乳期每日服用81毫克剂量的阿司匹林应被视为安全。
