使用葡萄糖酸锑钠治疗皮肤利什曼病的病灶内疗法。

Intralesional therapy of cutaneous leishmaniasis with sodium stibogluconate antimony.

作者信息

Sharquie K E, Al-Talib K K, Chu A C

机构信息

Department of Dermatology, College of Medicine, University of Baghdad, Iraq.

出版信息

Br J Dermatol. 1988 Jul;119(1):53-7. doi: 10.1111/j.1365-2133.1988.tb07100.x.

DOI:10.1111/j.1365-2133.1988.tb07100.x

PMID:2841964

Abstract

One hundred and thirty lesions of cutaneous leishmaniasis in 60 patients were treated with intralesional injections of Pentostam and 30 lesions were left untreated as controls. The injections were given at 8-day intervals and the patients followed-up for 42 days. One hundred and four lesions (80%) needed one injection only, 20 (15.4%) needed two and six (4.6%) needed three injections. One hundred and twenty three of the treated lesions (94.6%) showed a good clinical response with complete healing or marked improvement within the follow-up period. None of the control lesions showed marked improvement or complete healing. Scarring was minimal or absent following healing of treated lesions. The only side-effect was some localized pain following the injection. We recommend intralesional Pentostam as a safe and effective method of treating acute cutaneous leishmaniasis.

摘要

对60例皮肤利什曼病患者的130处皮损采用五价锑葡萄糖酸铵病灶内注射进行治疗，30处皮损未接受治疗作为对照。每隔8天进行一次注射，并对患者随访42天。104处皮损（80%）仅需注射一次，20处（15.4%）需注射两次，6处（4.6%）需注射三次。123处接受治疗的皮损（94.6%）在随访期内临床反应良好，实现了完全愈合或显著改善。对照皮损均未出现显著改善或完全愈合。治疗后的皮损愈合后瘢痕形成极少或无瘢痕形成。唯一的副作用是注射后出现一些局部疼痛。我们推荐病灶内注射五价锑葡萄糖酸铵作为治疗急性皮肤利什曼病的一种安全有效的方法。