Sharquie K E
Department of Dermatology, College of Medicine, University of Baghdad, Iraq.
J Dermatol. 1995 Oct;22(10):732-7. doi: 10.1111/j.1346-8138.1995.tb03911.x.
One hundred and fifty-eight lesions of acute cutaneous leishmaniasis in 70 patients were treated with hypertonic sodium chloride solution "HSCS" (88 lesions) or sodium stibogluconate (50 lesions); 20 lesions were left untreated as controls. The injections were given at 7-10 day intervals, and patients were followed-up for 42 days. "HSCS" was shown to be a very effective local therapy (96.05% cure rate) and was as effective as local sodium stibogluconate (96.42% cure rate). With both types of therapy, most lesions needed only one injection. Mild improvement was noticed 7-10 days after the first injection, and the cure was complete within 2-6 weeks (mean 4 weeks) of follow-up. None of the control lesions showed a cure within the six weeks follow-up. The mechanisms of action of both "HSCS" and sodium stibogluconate probably involve interference with the osmotic pressure of the cell cytoplasm of the parasites and lesional tissues. Scarring was either absent or minimal following healing of the treated lesions with both types of treatment. Post-inflammatory hyperpigmentation was observed in all patients. We strongly recommend intralesional "HSCS" as a cheap, safe, and effective local method for treating cutaneous leishmaniasis.
对70例急性皮肤利什曼病患者的158处皮损进行了治疗，其中88处皮损采用高渗氯化钠溶液（“HSCS”）治疗，50处皮损采用葡萄糖酸锑钠治疗；20处皮损未接受治疗作为对照。每隔7 - 10天进行一次注射，并对患者进行42天的随访。结果显示“HSCS”是一种非常有效的局部治疗方法（治愈率为96.05%），与局部使用葡萄糖酸锑钠的效果相当（治愈率为96.42%）。两种治疗方式下，大多数皮损仅需注射一次。首次注射后7 - 10天可见轻度改善，随访2 - 6周（平均4周）内治愈完成。在六周的随访期内，对照皮损均未出现治愈情况。“HSCS”和葡萄糖酸锑钠的作用机制可能都涉及干扰寄生虫和皮损组织细胞质的渗透压。两种治疗方式治疗后的皮损愈合后均无瘢痕形成或瘢痕极小。所有患者均出现了炎症后色素沉着。我们强烈推荐皮损内注射“HSCS”作为一种治疗皮肤利什曼病的廉价、安全且有效的局部方法。
