Pic P, Bouquin J P, el Atiq F
Institut de Chimie Biologique (UA 202 CNRS), Université de Provence, Marseille, France.
Biol Neonate. 1988;53(6):346-54. doi: 10.1159/000242812.
The cAMP synthesis by fetal rat thyroids is stimulated in vitro by thyrotropin (TSH) or forskolin during the 5 last days of intrauterine life. The effects are TSH- or forskolin-dose-dependent with equal responses to 20 mIU.ml-1 TSH or to 1 microM forskolin. The magnitude of the responses to TSH or to forskolin decreases significantly as the fetus is ageing. Since forskolin effects bypass hormone receptors, the adenylate cyclase activity can be concluded to decrease during the end of gestation probably in relation with thyroid iodine accumulation. The responses to TSH and forskolin becoming synergic between 19 1/2 and 21 1/2 days indicate modifications of adenylate cyclase properties probably related to some maturation of the enzyme.
在子宫内生活的最后5天，促甲状腺激素（TSH）或福斯高林可在体外刺激胎鼠甲状腺合成环磷酸腺苷（cAMP）。这些作用呈TSH或福斯高林剂量依赖性，对20 mIU/ml TSH或1 μM福斯高林的反应相同。随着胎儿的生长，对TSH或福斯高林的反应幅度显著降低。由于福斯高林的作用绕过激素受体，可以得出结论，腺苷酸环化酶活性在妊娠末期可能与甲状腺碘积累有关而降低。在19.5至21.5天之间，对TSH和福斯高林的反应变得协同，这表明腺苷酸环化酶特性的改变可能与该酶的某些成熟有关。
