福司可林能刺激环磷酸腺苷（cAMP）的产生，并在体外诱导胎鼠甲状腺功能分化的开始。
Forskolin stimulates cAMP production and the onset of the functional differentiation in the fetal rat thyroid in vitro.
作者信息
Pic P, Michel-Bechet M, el Atiq F, Athouel-Haon A M
出版信息
Biol Cell. 1986;57(3):231-7. doi: 10.1111/j.1768-322x.1986.tb00478.x.
Abstract
Forskolin, a diterpen stimulating the adenylcyclase induces in vitro an accumulation of cAMP in thyroid glands explanted from 17 day-old rat fetuses. Thyroid glands from 15 day-old fetuses exposed to forskolin exhibit, within 24 hr, an active folliculogenesis and 125I fixation in follicular cavities. The results indicate that cAMP probably activates the onset of both morphological and physiological maturation in the fetal rat thyroid.
摘要
福斯可林是一种刺激腺苷酸环化酶的二萜类化合物，它能在体外诱导从17日龄大鼠胎儿取出的甲状腺组织中cAMP的积累。暴露于福斯可林的15日龄胎儿的甲状腺在24小时内表现出活跃的卵泡发生以及卵泡腔对125I的摄取。结果表明，cAMP可能激活了胎鼠甲状腺形态和生理成熟的起始过程。
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