来自越南软珊瑚短指软珊瑚的细胞毒性甾体衍生物。
Cytotoxic steroid derivatives from the Vietnamese soft coral Sinularia brassica.
作者信息
Tran Hong Hanh Thi, Nguyen Viet Phong, Nguyen Van Thanh, Tran Huong Thu, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh
机构信息
a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
b School of Chemical Engineering , Hanoi University of Science and Technology , Hanoi , Vietnam.
出版信息
J Asian Nat Prod Res. 2017 Dec;19(12):1183-1190. doi: 10.1080/10286020.2017.1307192. Epub 2017 Apr 19.
Using various chromatographic separations, six ergostane-type steroids, including one new compound sinubrassione (1), and two pregnene-type steroid glycosides, including one new compound sinubrassioside (7), were isolated from methanol extract of the Vietnamese soft coral Sinularia brassica. The structure elucidation was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS. The cytotoxic activities of all the isolated compounds against three human cancer cell lines were also evaluated using MTT-based colorimetric assays.
通过各种色谱分离方法，从越南软珊瑚中华小棒软珊瑚（Sinularia brassica）的甲醇提取物中分离出六种麦角甾烷型甾体，包括一种新化合物中华小棒甾酮（1），以及两种孕甾烯型甾体糖苷，包括一种新化合物中华小棒苷（7）。通过包括一维、二维核磁共振和高分辨电喷雾电离质谱在内的光谱方法确定了其结构。还使用基于MTT的比色法评估了所有分离化合物对三种人类癌细胞系的细胞毒性活性。
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