来自越南软珊瑚团块肉芝软珊瑚的细胞毒性甾体化合物。
Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta.
作者信息
Ngoc Ninh Thi, Huong Pham Thi Mai, Thanh Nguyen Van, Chi Nguyen Thi Phuong, Dang Nguyen Hai, Cuong Nguyen Xuan, Nam Nguyen Hoai, Thung Do Cong, Kiem Phan Van, Minh Chau Van
机构信息
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
出版信息
Chem Pharm Bull (Tokyo). 2017 Mar 1;65(3):300-305. doi: 10.1248/cpb.c16-00881. Epub 2017 Jan 12.
Twelve steroids, including five new compounds 1-5, were isolated and structurally elucidated from a methanol extract of the Vietnamese soft coral Sinularia conferta. Their cytotoxic effects against three human cancer cell lines, lung carcinoma (A-549), cervical adenocarcinoma (HeLa), and pancreatic epithelioid carcinoma (PANC-1), were evaluated using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assays. Among isolated compounds, 10 exhibited potent cytotoxic effects on all three tested cell lines with IC values of 3.64±0.18, 19.34±0.42, and 1.78±0.69 µM, respectively.
从越南软珊瑚Sinularia conferta的甲醇提取物中分离并鉴定了12种甾体化合物，其中包括5种新化合物1-5。使用3-(4,5-二甲基噻唑-2)-2,5-二苯基四氮唑溴盐(MTT)法评估了它们对三种人类癌细胞系的细胞毒性作用，这三种细胞系分别是肺癌(A-549)、宫颈腺癌(HeLa)和胰腺上皮样癌(PANC-1)。在分离出的化合物中，有10种对所有三种测试细胞系均表现出强大的细胞毒性作用，其IC值分别为3.64±0.18、19.34±0.42和1.78±0.69µM。
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