Department of Chemistry, University of Nevada, Reno, Reno, NV 89557, USA.
Molecules. 2018 Oct 25;23(11):2768. doi: 10.3390/molecules23112768.
Metabolomics has become a powerful tool in chemical biology. Profiling the human sterolome has resulted in the discovery of noncanonical sterols, including oxysterols and meiosis-activating sterols. They are important to immune responses and development, and have been reviewed extensively. The triterpenoid metabolite fusidic acid has developed clinical relevance, and many steroidal metabolites from microbial sources possess varying bioactivities. Beyond the prospect of pharmacognostical agents, the profiling of minor metabolites can provide insight into an organism's biosynthesis and phylogeny, as well as inform drug discovery about infectious diseases. This review aims to highlight recent discoveries from detailed sterolomic profiling in microorganisms and their phylogenic and pharmacological implications.
代谢组学已成为化学生物学的有力工具。对人类甾醇组的分析导致了非典型甾醇的发现，包括氧化甾醇和减数分裂激活甾醇。它们对免疫反应和发育很重要，并且已经得到了广泛的研究。三萜酸代谢产物夫西地酸具有重要的临床意义，许多微生物来源的甾体代谢产物具有不同的生物活性。除了作为药物鉴定剂的前景外，对微量代谢物的分析可以深入了解生物体的生物合成和系统发育，并为传染病的药物发现提供信息。本综述旨在强调从微生物的详细甾醇组分析中获得的最新发现及其在系统发育和药理学方面的意义。
