[氯化锂导致大鼠酒精自愿摄入量减少时的生化变化]
[Biochemical changes in a decrease in the voluntary consumption of alcohol by rats due to lithium chloride].
作者信息
Tarasov Iu A, Satanovskaia V I, Ostrovskiĭ Iu M, Patsenko A A, Grinevich V P
出版信息
Farmakol Toksikol. 1988 May-Jun;51(3):94-7.
PMID:2842183
Abstract
A decrease of alcohol intake by ethanol-preferring rats under free choice conditions after intraperitoneal administration of lithium chloride (35 mg/kg) was accompanied by an activation of aldehyde dehydrogenase in the brain stem, a decrease of dopamine and salsolinol levels in the striatum and normalization of 11-hydroxycorticosteroids contents in the blood and adrenal glands.
摘要
腹腔注射氯化锂（35毫克/千克）后，在自由选择条件下，偏爱乙醇的大鼠酒精摄入量减少，同时脑干中醛脱氢酶被激活，纹状体中多巴胺和四氢异喹啉水平降低，血液和肾上腺中11-羟基皮质类固醇含量恢复正常。
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