Liubimov B I, Iavorskiĭ A N
Farmakol Toksikol. 1978 Mar-Apr;41(2):138-42.
Lithium chloride with its intraperitoneal administration to rats in a dose of 35 mg/kg, twice a day for 14 days, is shown to suppress predelection for ethanol formed by a 2-month consumption of its 5% solution. This effect of the lithium salt correlates with normalization of the activity displayed by central biorhythms regulators--neurosecretory hypothalamus, nuclei, earlier disorganized by ethanol. A possible relation between the ability of the lithium salts to normalize the central regulation of the biorhythms and their high therapeutic effectiveness in dealing with affective disturbances with a periodic course is discussed.
给大鼠腹腔注射氯化锂，剂量为35毫克/千克，每天两次，共14天，结果显示可抑制大鼠对因饮用5%乙醇溶液达2个月所形成的乙醇的偏好。锂盐的这一作用与中枢生物节律调节者——神经分泌性下丘脑核团的活性恢复正常相关，该核团早期因乙醇而紊乱。文中讨论了锂盐使生物节律的中枢调节恢复正常的能力与其在治疗周期性情感障碍方面的高治疗效果之间可能存在的关系。
