Department of Invasive Cardiology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland.
Mossakowski Research Science Center, Polish Academy of Science, Warsaw, Poland.
Cardiovasc Ther. 2017 Aug;35(4). doi: 10.1111/1755-5922.12267.
The optimal treatment strategy for coronary bifurcation lesions is still unknown. The aim of the study was to assess applicability of the new cobalt-chromium version of the sirolimus-eluting dedicated bifurcation BiOSS LIM C stent in comparison with regular sirolimus-eluting Orsiro stent in a porcine coronary model.
A total of 13 BiOSS LIM C stents and 6 Orsiro stents were implanted in normal nonatherosclerotic porcine straight coronary arteries of six animals using 1.2:1.0 stent-to-artery ratio. Stent geometry and morphology were evaluated by Faxitron imaging. Vascular response was assessed by quantitative coronary angiography (QCA), optical coherence tomography (OCT), and histological analyses.
OCT performed at 28 days confirmed that all stents were patent with no signs of thrombus. In morphometric analysis, no differences between groups regarding stent diameter (P=.141), neointima area (P=.247), % area stenosis (P=.293), or % diameter stenosis (P=.069) were observed. Also, no significant differences were noted between groups regarding their histopathology scores. The injury and inflammation scores were low (mean grade<1) in all groups.
The novel BiOSS LIM C stent demonstrates good short-term vascular effects in a porcine coronary bifurcation model which are comparable with Orsiro stents.
冠状动脉分叉病变的最佳治疗策略仍不清楚。本研究旨在评估新型钴铬版西罗莫司洗脱专用分叉 BiOSS LIM C 支架在猪冠状动脉模型中与常规西罗莫司洗脱 Orsiro 支架相比的适用性。
在 6 只动物的正常非动脉粥样硬化猪直冠状动脉中，以 1.2:1.0 的支架-动脉比，使用 13 个 BiOSS LIM C 支架和 6 个 Orsiro 支架进行植入。采用 Faxitron 成像评估支架的几何形状和形态。通过定量冠状动脉造影（QCA）、光学相干断层扫描（OCT）和组织学分析评估血管反应。
28 天时进行的 OCT 检查证实所有支架均通畅，无血栓迹象。在形态计量学分析中，两组支架直径（P=.141）、新生内膜面积（P=.247）、%面积狭窄（P=.293）或%直径狭窄（P=.069）均无差异。此外，两组的组织病理学评分也无显著差异。所有组的损伤和炎症评分均较低（平均等级<1）。
新型 BiOSS LIM C 支架在猪冠状动脉分叉模型中显示出良好的短期血管效果，与 Orsiro 支架相当。
