Hartung H P, Heininger K, Toyka K V
Department of Neurology, University of Düsseldorf, F.R.G.
J Neuroimmunol. 1988 Sep;19(3):237-43. doi: 10.1016/0165-5728(88)90005-7.
Astrocytes are important elements of cellular immune responses in the central nervous system. Eicosanoids exhibit immunomodulatory properties. We studied whether astroglial cells have the capacity to convert arachidonic acid via the lipoxygenase pathway to leukotriene B4 (LTB4). Calcium ionophore A23187 evoked a dose-related release of LTB4 into supernatants of primary culture rat astrocytes. This stimulatory effect was abrogated by the addition of the lipoxygenase inhibitors BW755c and nordihydroguaretic acid. Astrocyte production of the phlogistic and immunoregulatory mediator LTB4 may be one mechanism by which these cells influence immunity and inflammation in the central nervous system.
星形胶质细胞是中枢神经系统细胞免疫反应的重要组成部分。类花生酸具有免疫调节特性。我们研究了星形胶质细胞是否有能力通过脂氧合酶途径将花生四烯酸转化为白三烯B4（LTB4）。钙离子载体A23187可引起原代培养大鼠星形胶质细胞上清液中LTB4呈剂量相关的释放。添加脂氧合酶抑制剂BW755c和去甲二氢愈创木酸可消除这种刺激作用。星形胶质细胞产生促炎和免疫调节介质LTB4可能是这些细胞影响中枢神经系统免疫和炎症的一种机制。
