Department of Emergency Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
Department of Emergency Medicine, Keçiören Training and Research Hospital, Ankara, Turkey.
Turk J Med Sci. 2017 Apr 18;47(2):653-657. doi: 10.3906/sag-1602-55.
BACKGROUND/AIM: The aim of this study is to identify the copeptin levels in patients presenting with carbon monoxide (CO) poisoning to the emergency department and to investigate its correlation with the neurological effects.
The study group consisted of patients presenting with CO poisoning and carboxyhemoglobin levels >10%. Blood samples for copeptin levels were obtained twice, first at presentation then at the fourth hour of observation. The data were analyzed using SPSS 16 for Windows.
The median copeptin levels of the patient group were identified as 0.63 (0.39-1.06) ng/mL at hour 0 and 0.41 (0.31-0.49) at hour 4. The copeptin levels of the control group were 0.34 (0.25-0.42) ng/mL and were significantly lower than those of the patient group (P < 0.000). According to our results, 0.345 ng/mL for plasma copeptin level as the best cut-off level may be used with sensitivity of 94.0% and specificity of 60%. The copeptin levels at hour 0 were statistically significantly higher in the neurologically affected patients than those not affected (P < 0.001).
In this study it was shown that blood copeptin levels increase in patients presenting to the emergency department with CO poisoning.
背景/目的：本研究旨在确定急诊就诊的一氧化碳（CO）中毒患者的 copeptin 水平，并探讨其与神经效应的相关性。
研究组由 CO 中毒且碳氧血红蛋白水平>10%的患者组成。两次采集 copeptin 水平的血液样本，首次在就诊时，然后在观察的第 4 小时。使用 SPSS 16 for Windows 分析数据。
患者组的 copeptin 中位数水平在 0 小时时为 0.63（0.39-1.06）ng/mL，在 4 小时时为 0.41（0.31-0.49）ng/mL。对照组的 copeptin 水平为 0.34（0.25-0.42）ng/mL，明显低于患者组（P < 0.000）。根据我们的结果，血浆 copeptin 水平为 0.345 ng/mL 可能作为最佳截断值，其灵敏度为 94.0%，特异性为 60%。在有神经影响的患者中，0 小时的 copeptin 水平明显高于无神经影响的患者（P < 0.001）。
本研究表明，急诊就诊的 CO 中毒患者的血液 copeptin 水平升高。
