Department of Emergency Medicine, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Department of Emergency Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey.
Hum Exp Toxicol. 2020 Mar;39(3):311-318. doi: 10.1177/0960327119886063. Epub 2019 Nov 3.
The aim of our study is to determine whether there is a change in the plasma levels of copeptin and there is a relationship among the plasma levels of carboxyhemoglobin (COHb), lactate, and copeptin levels in patients presenting to the emergency department with carbon monoxide (CO) poisoning.
Fifty-seven patients admitted to the emergency department with CO poisoning were included in the study. The blood samples of the patients were collected on arrival 0th, 6th, and 12th hours for copeptin, lactate, and COHb levels. Data were analyzed using SPSS-17 statistical software.
Arrival serum copeptin levels of the patients were compared to copeptin levels of healthy individuals and a statistically significant difference was found between them ( = 0.008). There was a statistically significant difference between the arrival levels of copeptin and 6th-hour ( = 0.006) and 12th-hour ( = 0.001) levels of copeptin. There was no significant difference between 6th-hour and 12th-hour copeptin levels ( = 0.51). In terms of serum lactate levels, there was a significant difference between arrival and 6th h ( < 0.001), arrival and 12th h ( < 0.001), and 6th and 12th h ( < 0.001). Likewise, in terms of serum COHb levels, there was a significant difference between arrival and 6th h ( < 0.001), arrival and 12th h ( < 0.001), and 6th and 12th h ( < 0.001). There was a positive correlation between COHb and lactate levels on arrival ( = 0.52; = 0.001).
Copeptin as a stress hormone can be used in the diagnosis and monitoring of patients with CO poisoning. However, the copeptin level was not superior to COHb and lactate levels.
本研究旨在确定一氧化碳（CO）中毒患者血浆中copeptin 水平是否发生变化，以及其与 COHb、乳酸水平之间是否存在相关性。
本研究纳入了 57 例因 CO 中毒而入住急诊科的患者。患者入院时、第 6 小时和第 12 小时采集血液样本，用于检测 copeptin、乳酸和 COHb 水平。数据分析采用 SPSS-17 统计软件。
患者入院时血清 copeptin 水平与健康个体进行比较，两者之间存在统计学差异（ = 0.008）。与第 6 小时（ = 0.006）和第 12 小时（ = 0.001）相比，入院时 copeptin 水平显著升高。第 6 小时和第 12 小时的 copeptin 水平之间没有显著差异（ = 0.51）。在血清乳酸水平方面，入院时与第 6 小时（ < 0.001）、入院时与第 12 小时（ < 0.001）、第 6 小时与第 12 小时（ < 0.001）之间均存在显著差异。同样，在血清 COHb 水平方面，入院时与第 6 小时（ < 0.001）、入院时与第 12 小时（ < 0.001）、第 6 小时与第 12 小时（ < 0.001）之间均存在显著差异。入院时 COHb 和乳酸水平呈正相关（ = 0.52； = 0.001）。
作为一种应激激素，copeptin 可用于 CO 中毒患者的诊断和监测。然而，其水平并不优于 COHb 和乳酸水平。
