Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Xinyang Vocational and Technical College, Xinyang 464000, China.
Mini Rev Med Chem. 2019;19(2):114-124. doi: 10.2174/1389557517666170417170609.
Oridonin is one of the major components isolated from Isodon rubescens, a traditional Chinese medicine, and it has been confirmed to exhibit many kinds of biological activities including anticancer, anti-inflammation, antibacterial and so on. However, the poor pharmaceutical property limits the clinical applications of oridonin. So many strategies have been explored in the purpose of improving the potencies of oridonin, and structure modification is one thus way. This review outlines the landscape of the recent development of oridonin derivatives with diverse pharmacological activities, mainly focusing on the biological properties, structure-activity relationships, and mechanism of actions.
冬凌草甲素是从中药冬凌草中分离得到的主要成分之一，已被证实具有多种生物活性，包括抗癌、抗炎、抗菌等。然而，较差的药物性质限制了冬凌草甲素的临床应用。因此，人们探索了许多策略来提高冬凌草甲素的效力，结构修饰就是其中一种方法。本综述概述了具有多种药理活性的冬凌草甲素衍生物的最新研究进展，主要集中在生物活性、构效关系和作用机制方面。
