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冬凌草甲素增溶和生物利用度提高的研究进展：综述

Solubility and Bioavailability Enhancement of Oridonin: A Review.

机构信息

College of pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

出版信息

Molecules. 2020 Jan 14;25(2):332. doi: 10.3390/molecules25020332.

DOI:10.3390/molecules25020332
PMID:31947574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7024198/
Abstract

Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.

摘要

冬凌草甲素（ORI）是一种来自中国草药的贝壳杉烷四环二萜类化合物，具有多种生物和药理活性，包括抗肿瘤、抗菌和抗炎作用。然而，由于其溶解度低和生物利用度差，ORI 的临床应用受到限制。为了克服这些缺点，已经探索了许多策略，如结构修饰、新剂型等。本文详细讨论了提高 ORI 溶解度和生物利用度的研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/d510ba658538/molecules-25-00332-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/91c79cb0feb8/molecules-25-00332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/5c52aeaf7239/molecules-25-00332-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/94822fa9c910/molecules-25-00332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/a08b394f36fc/molecules-25-00332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/51606f6c488f/molecules-25-00332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/1dc83deee03d/molecules-25-00332-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/0d0df7562798/molecules-25-00332-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/d510ba658538/molecules-25-00332-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/91c79cb0feb8/molecules-25-00332-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/94822fa9c910/molecules-25-00332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/a08b394f36fc/molecules-25-00332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/51606f6c488f/molecules-25-00332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/1dc83deee03d/molecules-25-00332-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/0d0df7562798/molecules-25-00332-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f653/7024198/d510ba658538/molecules-25-00332-g009.jpg

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