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通过转录后和翻译后修饰对维生素D受体（VDR）活性进行微调。

Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications.

作者信息

Zenata Ondrej, Vrzal Radim

机构信息

Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic.

出版信息

Oncotarget. 2017 May 23;8(21):35390-35402. doi: 10.18632/oncotarget.15697.

DOI:10.18632/oncotarget.15697
PMID:28427151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5471063/
Abstract

Vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Activated VDR is responsible for maintaining calcium and phosphate homeostasis, and is required for proper cellular growth, cell differentiation and apoptosis. The expression of both phases I and II drug-metabolizing enzymes is also regulated by VDR, therefore it is clinically important.Post-translational modifications of NRs have been known as an important mechanism modulating the activity of NRs and their ability to drive the expression of target genes. The aim of this mini review is to summarize the current knowledge about post-transcriptional and post-translational modifications of VDR.

摘要

维生素D受体（VDR）是配体激活转录因子的核受体（NR）超家族的成员。活化的VDR负责维持钙和磷的稳态，是细胞正常生长、细胞分化和凋亡所必需的。I相和II相药物代谢酶的表达也受VDR调节，因此具有重要临床意义。核受体的翻译后修饰是调节核受体活性及其驱动靶基因表达能力的重要机制。本综述旨在总结目前关于VDR转录后和翻译后修饰的知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd7/5471063/077c6f2583b8/oncotarget-08-35390-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd7/5471063/2ee3ba0a5632/oncotarget-08-35390-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd7/5471063/737dc7df43b7/oncotarget-08-35390-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd7/5471063/077c6f2583b8/oncotarget-08-35390-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd7/5471063/2ee3ba0a5632/oncotarget-08-35390-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd7/5471063/737dc7df43b7/oncotarget-08-35390-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd7/5471063/077c6f2583b8/oncotarget-08-35390-g003.jpg

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