Department of Environmental Medicine and Infectious Disease, Graduate School of Medical Sciences, Kyushu University.
Department of General Internal Medicine, Kyushu University Hospital.
J Atheroscler Thromb. 2017 Oct 1;24(10):1023-1030. doi: 10.5551/jat.39735. Epub 2017 Apr 20.
To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population.
Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured.
The median endostatin level was 63.7 ng/mL (interquartile ranges: 49.7-93.2 ng/mL), and the mean carotid IMT was 0.68±0.12 mm. Residents with above median endostatin had significantly higher carotid IMT than did those with below median endostatin (0.71±0.14 vs. 0.65±0.09 mm, P＜0.001). Multiple linear regression analysis demonstrated that increased serum endostatin is significantly associated with carotid IMT (above vs. below median endostatin level; beta=0.11, P=0.03), independent of the known covariates of age, sex, body mass index, drinking and smoking status, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, low density lipoprotein cholesterol, estimated glomerular filtration rate, and log-transformed high sensitive C-reactive protein.
A higher serum endostatin level reflected subclinical atherosclerosis in this Japanese population.
在健康的日本人群中，独立于传统危险因素，研究血清内皮抑素水平与亚临床动脉粥样硬化之间的关系。
在 2010 年至 2011 年期间参加免费公共体检的 1057 名居民中，我们评估了 648 名健康居民的数据，这些居民成功测量了血清内皮抑素水平和颈总动脉内膜中层厚度（IMT）。
中位内皮抑素水平为 63.7ng/ml（四分位间距：49.7-93.2ng/ml），平均颈动脉 IMT 为 0.68±0.12mm。内皮抑素水平高于中位数的居民颈动脉 IMT 显著高于内皮抑素水平低于中位数的居民（0.71±0.14 vs. 0.65±0.09mm，P＜0.001）。多元线性回归分析表明，血清内皮抑素升高与颈动脉 IMT 显著相关（高于 vs. 低于中位数内皮抑素水平；β=0.11，P=0.03），独立于年龄、性别、体重指数、饮酒和吸烟状况、收缩压、舒张压、血红蛋白 A1c、低密度脂蛋白胆固醇、估算肾小球滤过率和高敏 C 反应蛋白的对数转换等已知协变量。
在本日本人群中，较高的血清内皮抑素水平反映了亚临床动脉粥样硬化。
